Prognostic, predictive, and therapeutic role of FGFR2 isoforms and cognate FGF ligands in endometrial cancer
Sengal, Asmerom Tesfamariam (2020) Prognostic, predictive, and therapeutic role of FGFR2 isoforms and cognate FGF ligands in endometrial cancer. PhD thesis, Queensland University of Technology.
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Asmerom Tesfamariam Sengal Thesis
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Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
This project investigated the role of FGFR2 isoforms (FGFR2b/FGFR2c) and their cognate FGF ligands in endometrial cancer development, prognosis, and treatment response via designing and validating an innovative BaseScope RNA in-situ hybridization assay and generating patient tumour-derived organoids. FGFR2c and high FGF18 expression were significantly associated with aggressive tumour characteristics and poor survival outcome. It was also noted FGFR2c expression is associated with progestin treatment failure in atypical hyperplasia and well-differentiated endometrial cancers. Overall, FGFR2c and FGF18 are independent prognostic biomarkers that could improve our ability to predict patient prognosis and predict response to FGFR inhibitor treatment in endometrial cancer.
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| ID Code: | 205851 |
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| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Pollock, Pamela & Williams, Elizabeth |
| Keywords: | Endometrial Cancer, Atypical Hyperplasia, Growth Factor, FGFR2, Progestin treatment, Prognostic biomarker, Molecular subtype, 3D Organoids, Targeted therapy, RNA ISH |
| DOI: | 10.5204/thesis.eprints.205851 |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 16 Nov 2020 14:50 |
| Last Modified: | 25 Jan 2025 00:45 |
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