Identification of proteins deregulated by platinum-based chemotherapy as novel biomarkers and therapeutic targets in non-small cell lung cancer
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75369309. Available under License Creative Commons Attribution 4.0. |
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Description
Platinum-based chemotherapy remains the cornerstone of treatment for most people with non-small cell lung cancer (NSCLC), either as adjuvant therapy in combination with a second cytotoxic agent or in combination with immunotherapy. Resistance to therapy, either in the form of primary refractory disease or evolutionary resistance, remains a significant issue in the treatment of NSCLC. Hence, predictive biomarkers and novel combinational strategies are required to improve the effectiveness and durability of treatment response 6for people with NSCLC. The aim of this study was to identify novel biomarkers and/or druggable proteins from deregulated protein networks within non-oncogene driven disease that are involved in the cellular response to cisplatin. Following exposure of NSCLC cells to cisplatin, in vitro quantitative mass spectrometry was applied to identify altered protein response networks. A total of 65 proteins were significantly deregulated following cisplatin exposure. These proteins were assessed to determine if they are druggable targets using novel machine learning approaches and to identify whether these proteins might serve as prognosticators of platinum therapy. Our data demonstrate novel candidates and drug-like molecules warranting further investigation to improve response to platinum agents in NSCLC.
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ID Code: | 208039 | ||||||||||||||
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Item Type: | Contribution to Journal (Journal Article) | ||||||||||||||
Refereed: | Yes | ||||||||||||||
ORCID iD: |
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Additional Information: | Acknowledgments: We thank members of the Cancer and Ageing Research Program for critical review of the manuscript. The work was supported by a Senior Clinical Research Fellowship (to KO’B), the Princess Alexandra Hospital (to KO’B), project grant funding from the Australian National Health and Medical Research Council and Cure Cancer Australia through the Cancer Australia Priority-driven Cancer Research Scheme (to MA) and an International Association for the Study of Lung Cancer Foundation (IASLC) Foundation Award (to MA and KO’B). NG acknowledges funding support from Advance Queensland Industry Research fellowship. We acknowledge computing time from the QUT high-performance computing facility and the NCI, Canberra. | ||||||||||||||
Measurements or Duration: | 13 pages | ||||||||||||||
DOI: | 10.3389/fonc.2021.615967 | ||||||||||||||
ISSN: | 2234-943X | ||||||||||||||
Pure ID: | 75369309 | ||||||||||||||
Divisions: | Current > Research Centres > Centre for Genomics and Personalised Health Current > QUT Faculties and Divisions > Faculty of Science Current > Schools > School of Chemistry & Physics Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
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Copyright Owner: | 2021 The Author(s) | ||||||||||||||
Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||||||||||
Deposited On: | 16 Feb 2021 01:54 | ||||||||||||||
Last Modified: | 28 Mar 2024 17:29 |
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