Poly(2-allylamidopropyl-2-oxazoline)-Based Hydrogels: From Accelerated Gelation Kinetics to in Vivo Compatibility in a Murine Subdermal Implant Model
Dargaville, Tim R., Harkin, Damien G., Park, Jong Ryul, Cavalcanti, Amanda, Bolle, Eleonore C.L., Savi, Flavia Medeiros, Farrugia, Brooke L., Monnery, Bryn D., Bernhard, Yann, Van Guyse, Joachim F.R., Podevyn, Annelore, & Hoogenboom, Richard (2021) Poly(2-allylamidopropyl-2-oxazoline)-Based Hydrogels: From Accelerated Gelation Kinetics to in Vivo Compatibility in a Murine Subdermal Implant Model. Biomacromolecules, 22(4), pp. 1590-1599.
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Description
A rapid photo-curing system based on poly(2-ethyl-2-oxazoline-co-2-allylamidopropyl-2-oxazoline) and its in vivo compatibility are presented. The base polymer was synthesized from the copolymerization of 2-ethyl-2-oxazoline (EtOx) and the methyl ester containing 2-methoxycarboxypropyl-2-oxazoline (C3MestOx) followed by amidation with allylamine to yield a highly water-soluble macromer. We showed that spherical hydrogels can be obtained by a simple water-in-oil gelation method using thiol-ene coupling and investigated the in vivo biocompatibility of these hydrogel spheres in a 28-day murine subdermal model. For comparison, hydrogel spheres prepared from poly(ethylene glycol) were also implanted. Both materials displayed mild, yet typical foreign body responses with little signs of fibrosis. This is the first report on the foreign body response of a poly(2-oxazoline) hydrogel, which paves the way for future investigations into how this highly tailorable class of materials can be used for implantable hydrogel devices.
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| ID Code: | 210247 | ||||||||
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| Item Type: | Contribution to Journal (Journal Article) | ||||||||
| Refereed: | Yes | ||||||||
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| Additional Information: | Funding Information: This project was performed with the approval of QUT’s Animal Research Ethics Committee (Project approval number: 1900000716). T.D. is supported by the ARC Future Fellowship scheme (FT150100408). This work was enabled by use of the Central Analytical Research Facility hosted by the Institute for Future Environments at QUT. The authors acknowledge the assistance of Auvro Mridha (University of Sydney) with performing the toxicity tests and Justin Large and Emily Goy (Translational Research Institute, Brisbane) for assistance with histology. | ||||||||
| Measurements or Duration: | 10 pages | ||||||||
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| DOI: | 10.1021/acs.biomac.1c00046 | ||||||||
| ISSN: | 1525-7797 | ||||||||
| Pure ID: | 83604868 | ||||||||
| Divisions: | Current > Research Centres > Centre for Materials Science Current > Research Centres > Centre for Transformative Biomimetics in Bioeng Current > Research Centres > Centre for Vision and Eye Research Current > QUT Faculties and Divisions > Faculty of Science Current > Schools > School of Chemistry & Physics Current > QUT Faculties and Divisions > Faculty of Engineering Current > Schools > School of Mechanical, Medical & Process Engineering Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
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| Funding Information: | This project was performed with the approval of QUT’s Animal Research Ethics Committee (Project approval number: 1900000716). T.D. is supported by the ARC Future Fellowship scheme (FT150100408). This work was enabled by use of the Central Analytical Research Facility hosted by the Institute for Future Environments at QUT. The authors acknowledge the assistance of Auvro Mridha (University of Sydney) with performing the toxicity tests and Justin Large and Emily Goy (Translational Research Institute, Brisbane) for assistance with histology. | ||||||||
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| Copyright Owner: | 2021 American Chemical Society | ||||||||
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| Deposited On: | 11 May 2021 15:39 | ||||||||
| Last Modified: | 06 Jun 2026 17:24 |
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