Long-Term Overconsumption of Sugar Starting at Adolescence Produces Persistent Hyperactivity and Neurocognitive Deficits in Adulthood
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Description
Sugar has become embedded in modern food and beverages. This has led to overconsumption of sugar in children, adolescents, and adults, with more than 60 countries consuming more than four times (>100 g/person/day) the WHO recommendations (25 g/person/day). Recent evidence suggests that obesity and impulsivity from poor dietary habits leads to further overconsumption of processed food and beverages. The long-term effects on cognitive processes and hyperactivity from sugar overconsumption, beginning at adolescence are not known. Using a well-validated mouse model of sugar consumption, we found that long-term sugar consumption, at a level that significantly augments weight gain, elicits an abnormal hyperlocomotor response to novelty and alters both episodic and spatial memory. Our results are similar to those reported in attention deficit and hyperactivity disorders. The deficits in hippocampal-dependent learning and memory were accompanied by altered hippocampal neurogenesis, with an overall decrease in the proliferation and differentiation of newborn neurons within the dentate gyrus. This suggests that long-term overconsumption of sugar, as that which occurs in the Western Diet might contribute to an increased risk of developing persistent hyperactivity and neurocognitive deficits in adulthood.
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ID Code: | 210924 | ||||||
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Item Type: | Contribution to Journal (Journal Article) | ||||||
Refereed: | Yes | ||||||
ORCID iD: |
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Additional Information: | Funding: This work was supported by National Health and Medical Research Council (NHMRC) (GNT1146417) to SEB. | ||||||
Measurements or Duration: | 15 pages | ||||||
Additional URLs: | |||||||
DOI: | 10.3389/fnins.2021.670430 | ||||||
ISSN: | 1662-4548 | ||||||
Pure ID: | 85942866 | ||||||
Divisions: | Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Clinical Sciences Current > Schools > School of Biomedical Sciences |
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Funding Information: | We are thankful to PACE animal facility manager Lisa Foster and her staff Miranda Sleath, Rachel Smith, and Annie Villalta-Burgett for the exquisite care of our animals. We are grateful to the imaging facility of the Translational Research Institute, the facility manager Sandrine Roy and the microscopy officer Ali Ju, and the School of Biomedical Sciences at University of Queensland, facility manager Shaun B. Walters for the extensive use of resources. Funding. This work was supported by National Health and Medical Research Council (NHMRC) (GNT1146417) to SEB. This work was supported by National Health and Medical Research Council (NHMRC) (GNT1146417) to SEB. | ||||||
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Copyright Owner: | 2021 The Author(s) | ||||||
Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||
Deposited On: | 08 Jun 2021 01:09 | ||||||
Last Modified: | 18 Apr 2024 11:13 |
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