Tumor Hypoxia Drives Genomic Instability
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86095150. Available under License Creative Commons Attribution 4.0. |
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Description
Cancer is a leading cause of death worldwide. As a common characteristic of cancer, hypoxia is associated with poor prognosis due to enhanced tumor malignancy and therapeutic resistance. The enhanced tumor aggressiveness stems at least partially from hypoxia-induced genomic instability. Therefore, a clear understanding of how tumor hypoxia induces genomic instability is crucial for the improvement of cancer therapeutics. This review summarizes recent developments highlighting the association of tumor hypoxia with genomic instability and the mechanisms by which tumor hypoxia drives genomic instability, followed by how hypoxic tumors can be specifically targeted to maximize efficacy.
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| ID Code: | 210992 | ||||||
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| Item Type: | Contribution to Journal (Review article) | ||||||
| Refereed: | Yes | ||||||
| ORCID iD: |
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| Additional Information: | Funding Information: This research work is financially supported by William and Hilde Chenhall Research Trust. | ||||||
| Measurements or Duration: | 10 pages | ||||||
| Keywords: | cancer therapeutic resistance, conceptual lethality, DNA damage repair, DNA damage response, genomic instability, HIF-1α, tumor hypoxia | ||||||
| DOI: | 10.3389/fcell.2021.626229 | ||||||
| ISSN: | 2296-634X | ||||||
| Pure ID: | 86095150 | ||||||
| Divisions: | Current > Research Centres > Centre for Genomics and Personalised Health Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
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| Funding Information: | This research work is financially supported by William and Hilde Chenhall Research Trust. | ||||||
| Copyright Owner: | 2021 The Author(s) | ||||||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||
| Deposited On: | 10 Jun 2021 03:43 | ||||||
| Last Modified: | 05 Aug 2024 22:50 |
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