Genetic epidemiology of endometrial cancer
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Pik Fang Kho Thesis
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Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
Endometrial cancer is the fifth most common cancer diagnosed in women in developed countries. This research used genetics to assess relationships between endometrial cancer and, previously identified and novel, risk factors. This work brings new insights by providing evidence that HDL and LDL cholesterol levels are linked to endometrial cancer risk. Further, I have shown that two gynaecological diseases, which are comorbid with endometrial cancer, also share genetic risk architecture with endometrial cancer. This work also advances the understanding of biological mechanisms of endometrial cancer by identifying candidate susceptibility genes.
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| ID Code: | 211383 |
|---|---|
| Item Type: | QUT Thesis (PhD by Publication) |
| Supervisor: | Batra, Jyotsna |
| Additional Information: | Recipient of a 2021 Outstanding Doctoral Thesis Award |
| Keywords: | endometrial cancer, genome-wide association study (GWAS), Mendelian randomisation, transcriptome-wide association study (TWAS), risk factors, genetic epidemiology, LDL cholesterol, HDL cholesterol, selenium, gene expression, ODTA |
| DOI: | 10.5204/thesis.eprints.211383 |
| Divisions: | Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 06 Jul 2021 05:28 |
| Last Modified: | 12 Dec 2022 04:50 |
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