Dissecting the role of tissue-specific cancer-associated fibroblasts in the prostate tumour microenvironment
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Anna Jaeschke Thesis
(PDF 152MB)
Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
Much of what we know today about prostate cancer is derived from studying cancer cells grown on a 2D plastic substrate, not representing the complex structure of a three-dimensional tumour. In this work, bioengineered cancer models provided physiologically relevant research platforms to gain novel insights into the interactions between different cell types present in the tumour. Distinct features of the cancerous and healthy tissues were found that have the potential to be explored for new diagnostic approaches. Advanced toolkits were developed to support the use of bioengineered models to their full potential, and to be utilised for further research questions.
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| ID Code: | 212448 |
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| Item Type: | QUT Thesis (PhD by Publication) |
| Supervisor: | Bray, Laura, Williams, Elizabeth, Vela, Ian, & Hutmacher, Dietmar W |
| Keywords: | cancer-associated fibroblasts, prostate cancer, tumour microenvironment, tumour models, bioengineered cancer models |
| DOI: | 10.5204/thesis.eprints.212448 |
| Divisions: | Current > QUT Faculties and Divisions > Faculty of Engineering Current > Schools > School of Mechanical, Medical & Process Engineering |
| Institution: | Queensland University of Technology |
| Deposited On: | 12 Aug 2021 02:23 |
| Last Modified: | 27 Jun 2022 14:00 |
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