Marked increase in proton pump inhibitors use in Australia
Description
Objectives: To examine the trends in the prescribing of subsidised proton pump inhibitors (PPIs) and histamine receptor antagonists (H2RAs), in the Australian population from 1995 to 2006 to encourage discussion regarding appropriate clinical use. PPIs and H2RAs are the second highest drug cost to the publicly subsidised Pharmaceutical Benefits Scheme (PBS). Design: Government data on numbers of subsidised scripts, quantity and doses for PPIs and H2RAs were analysed by gender and age, dose and indication. Main outcome measure: Drug utilisation as DDD [defined daily dose]/1000 population/day. Results: The use of combined PPIs increased by 1318%. Utilisation increased substantially after the relaxation of the subsidised indications for PPIs in 2001. Omeprazole had the largest market share but was substituted by its S-enantiomer esomeprazole after its introduction in 2002. There was considerable use in the elderly with the peak use being in those aged 80 years and over. The utilisation of H2RAs declined 72% over 12 years. Conclusions: PPI use has increased substantially, not only due to substitution of H2RAs but to expansion in the overall market. Utilisation does not appear to be commensurate with prevalence of gastro-oesophageal reflux disease (GORD) nor with prescribing guidelines for PPIs, with significant financial costs to patients and PBS. This study encourages clinical discussion regarding quality use of these medicines. © 2010 John Wiley & Sons, Ltd.
Impact and interest:
Citation counts are sourced monthly from Scopus and Web of Science® citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.
ID Code: | 218136 | ||
---|---|---|---|
Item Type: | Contribution to Journal (Journal Article) | ||
Refereed: | Yes | ||
ORCID iD: |
|
||
Measurements or Duration: | 6 pages | ||
Keywords: | 80 and over, Adolescent, Adult, Aged, Australia, Child, Drug Costs, Gastro-oesophageal reflux disease, Gastrointestinal Agents, Heartburn, Helicobacter infection, Histamine H2 Antagonists, Humans, Middle Aged, Pharmacopoeias as Topic, Physician's Practice Patterns, Preschool, Prescribing, Proton pump inhibitors, Utilisation, Young Adult, aged, article, cimetidine, drug cost, drug marketing, drug utilization, esomeprazole, famotidine, female, gastroesophageal reflux, human, lansoprazole, major clinical study, male, nizatidine, omeprazole, pantoprazole, peptic ulcer, prescription, priority journal, proton pump inhibitor, rabeprazole, ranitidine, treatment indication | ||
DOI: | 10.1002/pds.1969 | ||
ISSN: | 1053-8569 | ||
Pure ID: | 32259038 | ||
Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation |
||
Copyright Owner: | Consult author(s) regarding copyright matters | ||
Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||
Deposited On: | 06 Nov 2021 10:01 | ||
Last Modified: | 04 Jun 2024 17:35 |
Export: EndNote | Dublin Core | BibTeX
Repository Staff Only: item control page