Epithelial-mesenchymal plasticity in circulating tumour cells from patients with metastatic cancers and PDX models
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Sara Hassan Thesis
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Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
There is growing concern about the relevance of epithelial mesenchymal plasticity (EMP) status of primary tumours in influencing their metastatic potential. Circulating tumour cells (CTCs) provide a window into the metastatic process, and molecular characterisation of CTCs could lead to better understanding of the mechanisms involved in the metastatic cascade. This thesis is an investigation of molecular characteristics of EMP in tumours and CTCs using patient-derived xenograft models and patient blood samples. The CTC heterogeneity observed emphasises the complexity in CTC isolation and classification and supports the increasingly recognised importance of the epithelial-mesenchymal hybrid state in cancer progression and metastasis.
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| ID Code: | 228621 |
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| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Thompson, Rik, Hiriyur Nagaraj, Shivashankar, & Williams, Elizabeth |
| Keywords: | Circulating tumour cells, circulating tumour cell clusters, epithelial mesenchymal plasticity, metastasis, hybrid cells, prostate cancer, breast cancer, spiral microfluidics, prostate specific antigen |
| DOI: | 10.5204/thesis.eprints.228621 |
| Divisions: | Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 23 Mar 2022 00:50 |
| Last Modified: | 23 Mar 2022 00:50 |
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