Effects of adolescent sucrose overconsumption on serotonin and dopamine signalling and associated maladaptive effects in adulthood
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Kate Matthews Thesis
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Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
High sugar diet contributes to the development of obesity. Recent research suggests that the brain responds to sugar overconsumption similar to drugs of abuse. It is unknown how sugar overconsumption impacts serotonin and dopamine which are critical to the brain’s reward system. This thesis characterises an animal model of sugar overconsumption to examine the relationship between dopamine/serotonin signalling and sugar intake. Our results suggest that sugar dependence negatively influences emotional behaviour and impulse control, dopamine/serotonin signalling and production of new neurons. Understanding how sugar affects the brain will allow the development of drugs to reduce sugar intake and obesity.
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| ID Code: | 228732 |
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| Item Type: | QUT Thesis (PhD by Publication) |
| Supervisor: | Bartlett, Selena, Chehrehasa, Fatemeh, & Belmer, Arnauld |
| Keywords: | Sucrose, Sugar addiction, Obesity, Serotonin, Dopamine, Anxiety, Depression, Impulsivity, Neurogenesis, Neuroplasticity |
| DOI: | 10.5204/thesis.eprints.228732 |
| Divisions: | Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Clinical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 22 Mar 2022 23:53 |
| Last Modified: | 22 Mar 2022 23:53 |
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