Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore

Wu, Degang, Dou, Jinzhuang, Chai, Xiaoran, Bellis, Claire, Wilm, Andreas, Shih, Chih Chuan, Soon, Wendy Wei Jia, Bertin, Nicolas, Lin, Clarabelle Bitong, Khor, Chiea Chuen, DeGiorgio, Michael, Cheng, Shanshan, Bao, Li, Karnani, Neerja, Hwang, William Ying Khee, Davila, Sonia, Tan, Patrick, Shabbir, Asim, Moh, Angela, Tan, Eng King, Foo, Jia Nee, Goh, Liuh Ling, Leong, Khai Pang, Foo, Roger S.Y., Lam, Carolyn Su Ping, Richards, Arthur Mark, Cheng, Ching Yu, Aung, Tin, Wong, Tien Yin, Ng, Huck Hui, Ackers-Johnson, Matthew Andrew, Aliwarga, Edita, Ban, Kenneth Hon Kim, Bertrand, Denis, Chambers, John C., Chan, Dana Leng Hui, Chan, Cheryl Xue Li, Chee, Miao Li, Chee, Miao Ling, Chen, Pauline, Chen, Yunxin, Chew, Elaine Guo Yan, Chew, Wen Jie, Chiam, Lynn Hui Yun, Chong, Jenny Pek Ching, Chua, Ivan, Cook, Stuart A., Dai, Wei, Dorajoo, Rajkumar, Foo, Chuan Sheng, Goh, Rick Siow Mong, Hillmer, Axel M., Irwan, Ishak D., Jaufeerally, Fazlur, Javed, Asif, Jeyakani, Justin, Koh, John Tat Hung, Koh, Jia Yu, Krishnaswamy, Pavitra, Kuan, Jyn Ling, Kumari, Neelam, Lee, Ai Shan, Lee, Seow Eng, Lee, Sheldon, Lee, Yen Ling, Leong, See Ting, Li, Zheng, Li, Peter Yiqing, Liew, Jun Xian, Liew, Oi Wah, Lim, Su Chi, Lim, Weng Khong, Lim, Chia Wei, Lim, Tingsen Benson, Lim, Choon Kiat, Loh, Seet Yoong, Lok, Au Wing, Chin, Calvin W.L., Majithia, Shivani, Maurer-Stroh, Sebastian, Meah, Wee Yang, Mok, Shi Qi, Nargarajan, Niranjan, Ng, Pauline, Ng, Sarah B., Ng, Zhenyuan, Ng, Jessica Yan Xia, Ng, Ebonne, Ng, Shi Ling, Nusinovici, Simon, Ong, Chin Thing, Pan, Bangfen, Pedergnana, Vincent, Poh, Stanley, Prabhakar, Shyam, Prakash, Kumar M., Quek, Ivy, Sabanayagam, Charumathi, See, Wei Qiang, Sia, Yee Yen, Sim, Xueling, Sim, Wey Cheng, So, Jimmy, Soon, Dinna K.N., Tai, E. Shyong, Tan, Nicholas Y., Tan, Louis C.S., Tan, Hong Chang, Tan, Wilson Lek Wen, Tandiono, Moses, Tay, Amanda, Thakur, Sahil, Tham, Yih Chung, Tiang, Zenia, Toh, Grace Li Xian, Tsai, Pi Kuang, Veeravalli, Lavanya, Verma, Chandra S., Wang, Ling, Wang, Min Rui, Wong, Wing Cheong, Xie, Zhicheng, Yeo, Khung Keong, Zhang, Liang, Zhai, Weiwei, Zhao, Yi, Liu, Jianjun, Wang, Chaolong, & other, and (2019) Large-Scale Whole-Genome Sequencing of Three Diverse Asian Populations in Singapore. Cell, 179(3), 736-749.e15.

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ID Code:	229997
Item Type:	Contribution to Journal (Journal Article)
Refereed:	Yes
Additional Information:	Funding Information: We acknowledge H.M. Kang, S. Das, A. Tan, F. Zhang, J. Terhorst, P.-R. Loh, and G. Hellenthal for helpful discussions and support from all participants and clinical research coordinators of the contributing cohorts and studies: the TTSH Healthy Control Workgroup, the SEED cohort, the Asian Sudden Cardiac Death in Heart Failure Study, the Singapore Heart Failure Outcomes and Phenotypes (SHOP) cohort, the Asian neTwork for Translational Research and Cardiovascular Trials (ATTRaCT), the Parkinson’s Disease Study, the Peranakan Genome Study, the Platinum Asian Genomes Project, the Bariatric Surgery Study, the National Heart Centre Singapore Biobank and SingHEART cohorts, and the GUSTO and S-PRESTO study groups. This study was supported by Singapore’s A∗STAR (core funding and IAF-PP H17/01/a0/007), BMRC (SPF2014/001, SPF2013/002, SPF2014/003, SPF2014/004, and SPF2014/005), NMRC (CIRG/1371/2013, CIRG/1417/2015, CIRG/1488/2018, CSA-SI/0012/2017, CG/017/2013, CG/M006/2017_NHCS, TCR/013-NNI/2014, STaR/0011/2012, STaR2013/001, STaR/014/2013, STaR/0026/2015, TCR/006-NUHS/2013, TCR/012-NUHS/2014, TCR/004-NUS/2008, TCR/012-NUHS/2014, and center grants 2010-13 and 2013-2017), NRF (NRFF2016-03), National University of Singapore, SingHealth and Duke-NUS, and Alexandra Health small innovative grant SIGII/15203 and funding from Huazhong University of Science and Technology, the Tanoto Foundation, the Lee Foundation, the Boston Scientific Investigator Sponsored Research Program and Bayer, the NSF (DEB-1753489), and the Alfred P. Sloan Foundation. The computation was partially performed on resources of the National Supercomputing Centre, Singapore (https://www.nscc.sg).
Measurements or Duration:	14 pages
Keywords:	admixture, Asian populations, demographic history, genetic diversity, GWAS, imputation, natural selection, population structure, precision medicine, whole-genome sequencing
DOI:	10.1016/j.cell.2019.09.019
ISSN:	0092-8674
Pure ID:	108713518
Divisions:	Past > Institutes > Institute of Health and Biomedical Innovation
Funding Information:	We acknowledge H.M. Kang, S. Das, A. Tan, F. Zhang, J. Terhorst, P.-R. Loh, and G. Hellenthal for helpful discussions and support from all participants and clinical research coordinators of the contributing cohorts and studies: the TTSH Healthy Control Workgroup, the SEED cohort, the Asian Sudden Cardiac Death in Heart Failure Study, the Singapore Heart Failure Outcomes and Phenotypes (SHOP) cohort, the Asian neTwork for Translational Research and Cardiovascular Trials (ATTRaCT), the Parkinson's Disease Study, the Peranakan Genome Study, the Platinum Asian Genomes Project, the Bariatric Surgery Study, the National Heart Centre Singapore Biobank and SingHEART cohorts, and the GUSTO and S-PRESTO study groups. This study was supported by Singapore's A?STAR (core funding and IAF-PP H17/01/a0/007), BMRC (SPF2014/001, SPF2013/002, SPF2014/003, SPF2014/004, and SPF2014/005), NMRC (CIRG/1371/2013, CIRG/1417/2015, CIRG/1488/2018, CSA-SI/0012/2017, CG/017/2013, CG/M006/2017_NHCS, TCR/013-NNI/2014, STaR/0011/2012, STaR2013/001, STaR/014/2013, STaR/0026/2015, TCR/006-NUHS/2013, TCR/012-NUHS/2014, TCR/004-NUS/2008, TCR/012-NUHS/2014, and center grants 2010-13 and 2013-2017), NRF (NRFF2016-03), National University of Singapore, SingHealth and Duke-NUS, and Alexandra Health small innovative grant SIGII/15203 and funding from Huazhong University of Science and Technology, the Tanoto Foundation, the Lee Foundation, the Boston Scientific Investigator Sponsored Research Program and Bayer, the NSF (DEB-1753489), and the Alfred P. Sloan Foundation. The computation was partially performed on resources of the National Supercomputing Centre, Singapore (https://www.nscc.sg). J.L. C.W. and H.H.N. conceptualized and supervised the project. D.W. J.D. X.C. S.C. L.B. M.D. and C.W. conducted analysis. D.W. J.D. X.C. C.B. A.W. C.C.S. W.W.J.S. N.B. C.C.K. C.W. and J.L. contributed to data generation and curation. N.K. S.D. P.T. A.S. A.M. E.-K.T. J.N.F. L.L.G. K.P.L. R.S.Y.F. C.S.P.L. A.M.R. C.-Y.C. T.A. and T.Y.W. contributed samples. C.W. and J.L. drafted the manuscript, and C.W. J.L. M.D. C.B.L. and all the primary authors reviewed, edited, and approved manuscript. The authors declare no competing interests. We acknowledge H.M. Kang, S. Das, A. Tan, F. Zhang, J. Terhorst, P.-R. Loh, and G. Hellenthal for helpful discussions and support from all participants and clinical research coordinators of the contributing cohorts and studies: the TTSH Healthy Control Workgroup, the SEED cohort, the Asian Sudden Cardiac Death in Heart Failure Study, the Singapore Heart Failure Outcomes and Phenotypes (SHOP) cohort, the Asian neTwork for Translational Research and Cardiovascular Trials (ATTRaCT), the Parkinson’s Disease Study, the Peranakan Genome Study, the Platinum Asian Genomes Project, the Bariatric Surgery Study, the National Heart Centre Singapore Biobank and SingHEART cohorts, and the GUSTO and S-PRESTO study groups. This study was supported by Singapore’s A ∗ STAR (core funding and IAF-PP H17/01/a0/007 ), BMRC ( SPF2014/001 , SPF2013/002 , SPF2014/003 , SPF2014/004 , and SPF2014/005 ), NMRC ( CIRG/1371/2013 , CIRG/1417/2015 , CIRG/1488/2018 , CSA-SI/0012/2017 , CG/017/2013 , CG/M006/2017_NHCS , TCR/013-NNI/2014 , STaR/0011/2012 , STaR2013/001 , STaR/014/2013 , STaR/0026/2015 , TCR/006-NUHS/2013 , TCR/012-NUHS/2014 , TCR/004-NUS/2008 , TCR/012-NUHS/2014 , and center grants 2010-13 and 2013-2017 ), NRF ( NRFF2016-03 ), National University of Singapore , SingHealth and Duke-NUS , and Alexandra Health small innovative grant SIGII/15203 and funding from Huazhong University of Science and Technology , the Tanoto Foundation , the Lee Foundation , the Boston Scientific Investigator Sponsored Research Program and Bayer , the NSF ( DEB-1753489 ), and the Alfred P. Sloan Foundation . The computation was partially performed on resources of the National Supercomputing Centre, Singapore ( https://www.nscc.sg ).
Copyright Owner:	2019 Elsevier Inc.
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Deposited On:	21 Apr 2022 06:15
Last Modified:	25 Jul 2024 17:33