Post-traumatic stress disorder affects fucose-alpha(1-2)-glycans in the human brain: preliminary findings of neuro deregulation using in vivo two-dimensional neuro MR spectroscopy
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108868703. Available under License Creative Commons Attribution 4.0. |
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Description
Post-traumatic stress disorder (PTSD) is triggered by experiencing terrifying event(s) for which there is currently no objective test for a definitive diagnosis. We report a pilot study where two-dimensional (2D) neuro magnetic resonance spectroscopy (MRS), collected at 3 T in a clinical scanner with a 64-channel head coil, identifies neuro deregulation in the PTSD cohort. The control subjects (n = 10) were compared with PTSD participants with minimal co-morbidities (n = 10). The 2D MRS identified statistically significant increases in the total spectral region containing both free substrate fucose and fucosylated glycans of 31% (P = 0.0013), two of multiple fucosylated glycans (Fuc IV and VI) were elevated by 48% (P = 0.002), and 41% (P = 0.02), respectively, imidazole was increased by 12% (P = 0.002), and lipid saturation was increased by 12.5% (P = 0.009). This is the first evidence of fucosylated glycans, reported in animals to be involved in learning and memory, to be affected in humans with PTSD.
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| ID Code: | 230183 | ||
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| Item Type: | Contribution to Journal (Journal Article) | ||
| Refereed: | Yes | ||
| ORCID iD: |
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| Additional Information: | Funding Information: We thank Professor Alexander McFarlane FRACP, Centre for Traumatic Stress Studies in Adelaide, for his support and assistance in establishing the correct evaluations for the PTSD cohort; Julie Mastrodomenico BSc for undertaking the early psychological evaluations; Valerie Graves MM for the initial management of the program and Dr Saad Ramadan PhD for assistance with the COSY code for each version of operating system. We thank Dr Alexander Murray, Dr Roger Peters and Frank De Mortel for their early help with recruitment. This study was funded by the Department of Defence of Australia and Department of Defence USA under the MOU and task plan PP-3664-9 concerning combating terrorism research and development and USA Departments of Defence; and the Advance Queensland funding initiative to establish The Translational Research Institute (TRI) Innovation and Translation Centre (IAT Centre) in co-operation with Siemens Healthcare. | ||
| Measurements or Duration: | 9 pages | ||
| DOI: | 10.1038/s41398-018-0365-6 | ||
| ISSN: | 2158-3188 | ||
| Pure ID: | 108868703 | ||
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation Current > Schools > School of Clinical Sciences |
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| Funding Information: | We thank Professor Alexander McFarlane FRACP, Centre for Traumatic Stress Studies in Adelaide, for his support and assistance in establishing the correct evaluations for the PTSD cohort; Julie Mastrodomenico BSc for undertaking the early psychological evaluations; Valerie Graves MM for the initial management of the program and Dr Saad Ramadan PhD for assistance with the COSY code for each version of operating system. We thank Dr Alexander Murray, Dr Roger Peters and Frank De Mortel for their early help with recruitment. This study was funded by the Department of Defence of Australia and Department of Defence USA under the MOU and task plan PP-3664-9 concerning combating terrorism research and development and USA Departments of Defence; and the Advance Queensland funding initiative to establish The Translational Research Institute (TRI) Innovation and Translation Centre (IAT Centre) in co-operation with Siemens Healthcare. | ||
| Copyright Owner: | 2019 The Author(s) | ||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||
| Deposited On: | 28 Apr 2022 01:52 | ||
| Last Modified: | 17 May 2024 15:19 |
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