Two New Fucose-alpha (1-2)-Glycans Assigned In The Healthy Human Brain Taking The Number To Seven
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110872318. Available under License Creative Commons Attribution 4.0. |
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Description
Fucosylated glycans are involved in the molecular mechanisms that underpin neuronal development, learning and memory. The capacity to study the fucose-α(1–2)-glycan residues noninvasively in the human brain, is integral to understanding their function and deregulation. Five fucose crosspeaks were assigned to fucosylated glycans using invivo two-dimensional magnetic resonance Correlated SpectroscopY (2D L-COSY) of the brain. Recent improvements encompassed on the 3T Prisma (Siemens, Erlangen) with a 64-channel head and neck coil have allowed two new assignments. These are Fuc VI (F2:4.44, F1:1.37 ppm) and Fuc VII (F2: 4.29, F1:1.36 ppm). The Fuc VI crosspeak, close to the water resonance, is resolved due to decreased T1 noise. Fuc VII crosspeak, located between Fuc I and III, is available for inspection due to increased spectral resolution. Spectra recorded from 33 healthy men and women showed a maximum variation of up to 0.02 ppm in chemical shifts for all crosspeaks.
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| ID Code: | 232116 | ||
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| Item Type: | Contribution to Journal (Journal Article) | ||
| Refereed: | Yes | ||
| ORCID iD: |
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| Additional Information: | Funding Information: The Queensland Government has supported this work under the “Advance Queensland” initiative and the Australian and US Departments of Defence Agreement 498030. | ||
| Measurements or Duration: | 8 pages | ||
| DOI: | 10.1038/s41598-019-54933-1 | ||
| ISSN: | 2045-2322 | ||
| Pure ID: | 110872318 | ||
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Current > Schools > School of Clinical Sciences |
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| Funding Information: | The Queensland Government has supported this work under the “Advance Queensland” initiative and the Australian and US Departments of Defence Agreement 498030. | ||
| Copyright Owner: | 2019 The Authors | ||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||
| Deposited On: | 03 Jun 2022 03:30 | ||
| Last Modified: | 14 Jun 2024 00:56 |
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