Pore architecture influences the enzyme immobilization performance of mesoporous silica nanospheres
Description
Immobilized enzymes on silica nano-carriers are stable biocatalysts with the potential for use in a plethora of applications. Studying how the structural characteristics of silica nano-carriers influence the performance of immobilized enzymes allows for the optimization of performance. This work investigates the influence of the pore architecture of silica nanospheres on enzyme loading, release, and reusability. Compared to dendritic mesoporous silica nanospheres (DMSN) with funnel-shaped wide-open pores, fractal silica nanoparticles (FSN) have a far more complex pore structure. FSN showed significantly higher immobilization capacity, sustained release, and enhanced reusability towards two model enzymes. The knowledge gained from this work paves the way for the rational design of enzyme nano-carriers for various applications.
Impact and interest:
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| ID Code: | 232306 | ||
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| Item Type: | Contribution to Journal (Journal Article) | ||
| Refereed: | Yes | ||
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| Additional Information: | Acknowledgement: The authors acknowledge the financial support from the Advance Queensland Innovation Partnerships (AQIP01515-16RD1)- Biomanufacturing Advanced Animal Feed Supplements. The authors also thank the support from the Australian Research Council, the Queensland Government, and the Australian Microscopy and Microanalysis Research Facility at the Centre for Microscopy and Microanalysis, the University of Queensland. This work was performed in part at the Queensland node of the Australian National Fabrication Facility, a company established under the National Collaborative Research Infrastructure Strategy to provide nano- and micro-fabrication facilities for Australia’s researchers. | ||
| Measurements or Duration: | 9 pages | ||
| Keywords: | Dendritic mesoporous silica nanoparticles, Enzyme immobilization, Fractal silica nanoparticles, Nano-carriers, Pore architecture | ||
| DOI: | 10.1016/j.micromeso.2022.111963 | ||
| ISSN: | 1387-1811 | ||
| Pure ID: | 110981046 | ||
| Divisions: | Current > Research Centres > Centre for Agriculture and the Bioeconomy Current > Research Centres > Centre for a Waste Free World Current > QUT Faculties and Divisions > Faculty of Science Current > Schools > School of Biology & Environmental Science |
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| Funding Information: | The authors acknowledge the financial support from the Advance Queensland Innovation Partnerships (AQIP01515-16RD1)- Biomanufacturing Advanced Animal Feed Supplements. The authors also thank the support from the Australian Research Council , the Queensland Government , and the Australian Microscopy and Microanalysis Research Facility at the Centre for Microscopy and Microanalysis, the University of Queensland . This work was performed in part at the Queensland node of the Australian National Fabrication Facility , a company established under the National Collaborative Research Infrastructure Strategy to provide nano- and micro-fabrication facilities for Australia’s researchers. | ||
| Copyright Owner: | 2022 Elsevier Inc. | ||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||
| Deposited On: | 07 Jun 2022 00:09 | ||
| Last Modified: | 25 May 2024 19:02 |
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