Laser Sintering Approaches for Bone Tissue Engineering
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112958960. Available under License Creative Commons Attribution 4.0. |
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Description
The adoption of additive manufacturing (AM) techniques into the medical space has revo-lutionised tissue engineering. Depending upon the tissue type, specific AM approaches are capable of closely matching the physical and biological tissue attributes, to guide tissue regeneration. For hard tissue such as bone, powder bed fusion (PBF) techniques have significant potential, as they are capable of fabricating materials that can match the mechanical requirements necessary to maintain bone functionality and support regeneration. This review focuses on the PBF techniques that utilize laser sintering for creating scaffolds for bone tissue engineering (BTE) applications. Optimal scaffold requirements are explained, ranging from material biocompatibility and bioactivity, to generating specific architectures to recapitulate the porosity, interconnectivity, and mechanical properties of native human bone. The main objective of the review is to outline the most common materials processed using PBF in the context of BTE; initially outlining the most common polymers, including polyamide, polycaprolactone, polyethylene, and polyetheretherketone. Subsequent sections investigate the use of metals and ceramics in similar systems for BTE applications. The last section explores how composite materials can be used. Within each material section, the benefits and shortcomings are outlined, including their mechanical and biological performance, as well as associated printing parameters. The framework provided can be applied to the development of new, novel materials or laser-based approaches to ultimately generate bone tissue analogues or for guiding bone regeneration.
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ID Code: | 233849 | ||||
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Item Type: | Contribution to Journal (Review article) | ||||
Refereed: | Yes | ||||
ORCID iD: |
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Additional Information: | Funding Information: The authors acknowledge the support of the Australian National Fabrication Facility (ANFF) Materials Node for their provision of equipment and materials, funding support from the Australian Research Council (ARC) Centre of Excellence Scheme (CE140100012). The support at the Translational Research Initiative for Cell Engineering and Printing (TRICEP) facilities. J.N. Dinoro and N.C. Paxton acknowledge the support of ARC Industrial Transformation Training Centre in Additive Biomanufacturing and industry partner, Anatomics Pty Ltd. | ||||
Measurements or Duration: | 29 pages | ||||
Keywords: | 3D printing, additive manufacturing, bone regeneration, implants, polymers, sintering | ||||
DOI: | 10.3390/polym14122336 | ||||
ISSN: | 2073-4360 | ||||
Pure ID: | 112958960 | ||||
Divisions: | Current > Research Centres > Centre for Biomedical Technologies Current > QUT Faculties and Divisions > Faculty of Engineering Current > Schools > School of Mechanical, Medical & Process Engineering |
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Funding Information: | Funding: The authors acknowledge the support of the Australian National Fabrication Facility (ANFF) Materials Node for their provision of equipment and materials, funding support from the Australian Research Council (ARC) Centre of Excellence Scheme (CE140100012). The support at the Translational Research Initiative for Cell Engineering and Printing (TRICEP) facilities. J.N. Dinoro and N.C. Paxton acknowledge the support of ARC Industrial Transformation Training Centre in Additive Biomanufacturing and industry partner, Anatomics Pty Ltd. The authors acknowledge the support of the Australian National Fabrication Facility (ANFF) Materials Node for their provision of equipment and materials, funding support from the Australian Research Council (ARC) Centre of Excellence Scheme (CE140100012). The support at the Translational Research Initiative for Cell Engineering and Printing (TRICEP) facilities. J.N. Dinoro and N.C. Paxton acknowledge the support of ARC Industrial Transformation Training Centre in Additive Biomanufacturing and industry partner, Anatomics Pty Ltd. | ||||
Copyright Owner: | 2022 The Authors | ||||
Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||
Deposited On: | 21 Jul 2022 00:48 | ||||
Last Modified: | 15 Jun 2024 21:06 |
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