Measuring contact angles on hydrophilic porous scaffolds by implementing a novel raised platform approach: A technical note
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113508802. Available under License Creative Commons Attribution Non-commercial 4.0. |
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Description
Contact angle (CA) analysis is a widely employed technique to assess the surface properties of solid samples, including in tissue engineering research where scaffolds are typically designed to be both porous and hydrophilic to enable cell and tissue infiltration. Paradoxically, the types of scaffolds that possess the most optimal hydrophilic surface properties for cell attachment are the most challenging surfaces to attain accurate CA measurements. Here, we propose the use of a small 3D printed platform to elevate samples above the CA measurement substrate and demonstrate reproducible and accurate CA measurements on a range of popular polymer scaffolds that had undergone 5 min plasma treatment to instigate hydrophilicity. Using four polycaprolactone or high-density polyethylene scaffolds with porosity ranging from 35.8%–93.1%, 0° CAs were reproducibly observed by measuring the CA while the scaffolds were elevated on the 3D printed platform, compared to the highly variable false-positive results when measuring the scaffolds while directly sitting on measurement substrates of various materials. This versatile, low-cost modification to CA hardware overcomes the challenges associated with measuring the surface properties of porous, hydrophilic scaffolds and provides a simple tool for tissue engineering researchers to perform CA measurements for any biomaterial scaffolds to ascertain hydrophilicity which is used to infer the suitability of scaffold surfaces for cell attachment.
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| ID Code: | 234211 | ||||
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| Item Type: | Contribution to Journal (Journal Article) | ||||
| Refereed: | Yes | ||||
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| Additional Information: | Funding Information: The authors wish to acknowledge Mr Trent Brooks-Richards for his assistance 3D printing the sample platform. StarPore® scaffolds were kindly supplied by Mr Robert Thompson, Vice-President Product Innovation, Anatomics Pty Ltd, Melbourne, Australia. The data reported was obtained using the resources of the Central Analytical Research Facility within the Research Infrastructure Division, Queensland University of Technology, with funding from the Faculty of Engineering. Open access publishing facilitated by Queensland University of Technology, as part of the Wiley - Queensland University of Technology agreement via the Council of Australian University Librarians. N.C. Paxton acknowledging funding from Advance Queensland (AQIRF2020), CSIRO, 3D Systems and Edale Capital, as well as from Queensland University of Technology (Early Career Research Scheme Grant), and QUT Centre for Biomedical Technologies (Industry Engagement Grant). | ||||
| Measurements or Duration: | 7 pages | ||||
| Keywords: | biomaterials, contact angles, scaffolds, wetting | ||||
| DOI: | 10.1002/pat.5792 | ||||
| ISSN: | 1042-7147 | ||||
| Pure ID: | 113508802 | ||||
| Divisions: | Current > Research Centres > Centre for Biomedical Technologies Current > QUT Faculties and Divisions > Faculty of Engineering Current > Schools > School of Mechanical, Medical & Process Engineering |
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| Funding Information: | The authors wish to acknowledge Mr Trent Brooks‐Richards for his assistance 3D printing the sample platform. StarPore® scaffolds were kindly supplied by Mr Robert Thompson, Vice‐President Product Innovation, Anatomics Pty Ltd, Melbourne, Australia. The data reported was obtained using the resources of the Central Analytical Research Facility within the Research Infrastructure Division, Queensland University of Technology, with funding from the Faculty of Engineering. Open access publishing facilitated by Queensland University of Technology, as part of the Wiley ‐ Queensland University of Technology agreement via the Council of Australian University Librarians. N.C. Paxton acknowledging funding from Advance Queensland (AQIRF2020), CSIRO, 3D Systems and Edale Capital, as well as from Queensland University of Technology (Early Career Research Scheme Grant), and QUT Centre for Biomedical Technologies (Industry Engagement Grant). Funding information | ||||
| Copyright Owner: | 2022 The Authors | ||||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||
| Deposited On: | 01 Aug 2022 02:43 | ||||
| Last Modified: | 05 Jul 2024 04:03 |
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