Brain GABA and glutamate levels across pain conditions: A systematic literature review and meta-analysis of 1H-MRS studies using the MRS-Q quality assessment tool
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115329661. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
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Description
Background: A proposed mechanism of chronic pain is dysregulation between the main inhibitory (GABA) and excitatory (glutamate) neurometabolites of the central nervous system. The level of these neurometabolites appears to differ in individual studies of people with pain compared to pain-free controls across different pain conditions. However, this has yet to be systematically investigated. Aims: To establish whether GABA, glutamate, glutamine and Glx levels differ across pain conditions when compared to pain-free controls. Methods: Five databases were searched. Studies were included if they investigated: 1) A pain condition compared to control. 2) Reported GABA, glutamate, glutamine or glutamate/glutamine level. 3) Used 1H-Magnetic Resonance Spectroscopy (Prospero Project ID CRD42018092170). Data extracted included neurometabolite level, pain diagnosis, and spectroscopy parameters. Meta-analyses were conducted to establish the difference in neurometabolite level between participants with pain and pain-free controls for different pain conditions. The MRS-Q was developed from existing clinical consensus to allow for the assessment of quality in the included studies. Results: Thirty-five studies were included investigating combinations of migraine (n = 11), musculoskeletal pain (n = 8), chronic pain syndromes (n = 9) and miscellaneous pain (n = 10). Higher GABA levels were found in participants with migraine compared to controls (Hedge's G 0.499, 95%CI: 0.2 to 0.798). In contrast, GABA levels in musculoskeletal pain conditions (Hedge's G −0.189, 95%CI: 0.530 to 0.153) and chronic pain syndromes (Hedge's G 0.077, 95%CI: 1.612 to 1.459) did not differ from controls. Results for other brain neurometabolites revealed significantly higher levels for glutamate in participants with migraine and Glx in chronic pain syndromes compared to controls. Conclusion: These results support the theory that underlying neurometabolite levels may be unique in different pain conditions and therefore representative of biomarkers for specific pain conditions.
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| ID Code: | 235189 | ||
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| Item Type: | Contribution to Journal (Journal Article) | ||
| Refereed: | Yes | ||
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| Additional Information: | Funding Information: Aimie Peek The University of Sydney, Australian Postgraduate Award and Top-up Scholarship National Health and Medical Research Council (NHMRC), Centre of Research Excellence in recovery following road Traffic Injuries, Australia. Assoc. Prof Trudy Rebbeck University of Sydney, Sydney Research Accelerator (SOAR) Fellowship and National Health and Medical Research Council (NHMRC) Career Development Fellowship, Australia. Dr Nicolaas Puts receives funding from the National Institutes of Health NIH R00 MH107719, USA. Julia Watson Queensland University of Technology - Translational Research Institute (TRI) Radiographer Research Scholarship, Australia. | ||
| Measurements or Duration: | 20 pages | ||
| Keywords: | Biomarker, GABA, Glutamate, Glutamine, MR spectroscopy, Pain | ||
| DOI: | 10.1016/j.neuroimage.2020.116532 | ||
| ISSN: | 1053-8119 | ||
| Pure ID: | 115329661 | ||
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Current > Schools > School of Clinical Sciences |
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| Funding Information: | Aimie Peek The University of Sydney, Australian Postgraduate Award and Top-up Scholarship National Health and Medical Research Council (NHMRC), Centre of Research Excellence in recovery following road Traffic Injuries, Australia.Assoc. Prof Trudy Rebbeck University of Sydney, Sydney Research Accelerator (SOAR) Fellowship and National Health and Medical Research Council (NHMRC) Career Development Fellowship, Australia.Dr Nicolaas Puts receives funding from the National Institutes of Health NIH R00 MH107719, USA.Julia Watson Queensland University of Technology - Translational Research Institute (TRI) Radiographer Research Scholarship, Australia. Dr Nicolaas Puts receives funding from the National Institutes of Health NIH R00 MH107719 , USA. Aimie Peek The University of Sydney , Australian Postgraduate Award and Top-up Scholarship National Health and Medical Research Council (NHMRC) , Centre of Research Excellence in recovery following road Traffic Injuries, Australia . | ||
| Copyright Owner: | 2020 The Authors | ||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||
| Deposited On: | 13 Sep 2022 02:05 | ||
| Last Modified: | 04 Aug 2024 04:52 |
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