Investigating the repertoire of DsbA enzymes in Klebsiella pneumoniae
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Description
Klebsiella pneumoniae is a clinically important bacterial pathogen causing urinary tract infections and pneumonia which can progress to more severe disease. With the increase in antimicrobial resistance globally, K. pneumoniae infections have become difficult to treat, with many antibiotics now ineffective. Therefore, it is imperative that we investigate new and effective treatments for these drug resistant infections. This thesis describes the identification and characterization of multiple diverse disulphide bond enzymes in K. pneumoniae that have potential as novel therapeutic targets.
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| ID Code: | 235382 |
|---|---|
| Item Type: | QUT Thesis (Master of Philosophy) |
| Supervisor: | Totsika, Makrina & Kenyon, Johanna |
| Keywords: | Klebsiella pneumoniae, antimicrobial resistance, anti-virulence, disulphide bond forming pathway, DsbA, oxidoreductase, bacterial pathogen |
| DOI: | 10.5204/thesis.eprints.235382 |
| Pure ID: | 115367767 |
| Divisions: | Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 29 Sep 2022 02:58 |
| Last Modified: | 24 Jan 2023 05:26 |
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