The Microwell-mesh platform: A multifaceted microtissue technology to link cell culture, animal models and patients
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Melissa Monterosso Thesis. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
Work towards effective translational medicine has revealed that current in vitro platforms are not sufficient to produce relevant clinical results. Advances in 3D technologies and preclinical models must be made to address the gaps lead to failure of initially promising therapies. The Microwell-mesh platform is a versatile device demonstrated to help bridge this gap. The device within the context of completed work was used to not only generate cancer xenograft models, crucial for successful personalized cancer therapeutics, but was also used to investigate the capacity of adult mesenchymal stem cells to regenerate bone and cartilage tissues within relevant biological environments.
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| ID Code: | 236375 |
|---|---|
| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Williams, Elizabeth & Doran, Michael |
| Keywords: | 3D Culture, microtissue, mesenchymal stem cells MSC, bone marrow mesenchymal stem cells BMSC, bone repair, patient derived xenograft PDX, prostate cancer, primary cells, regenerative therapies, translational research |
| DOI: | 10.5204/thesis.eprints.236375 |
| Pure ID: | 117639831 |
| Divisions: | Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 17 Nov 2022 06:08 |
| Last Modified: | 25 Jan 2023 03:38 |
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