Antibacterial Potential of Extracts and Phytoconstituents Isolated from Syncarpia hillii Leaves In Vitro
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Description
(1) Background: Rapidly increasing antibiotic resistance is one of the greatest threats to global health, affecting individuals regardless of age. Medicinal plants are widely used in traditional medicine to prevent and attenuate infectious conditions with minimal adverse effects. However, only a few have been phytochemically investigated for their medicinal properties and subsequent biological activities. Syncarpia hillii, a plant traditionally used by Indigenous Australians to treat sores, wounds, and skin infections, is no exception. (2) Methods: Primary extracts obtained from mature S. hillii leaves were evaluated for their antibacterial potential against 19 bacterial strains. The methanol extract was subjected to compound isolation and identification due to its preliminary bactericidal efficacy. (3) Results: Staphylococcal species were the most susceptible bacterial strain with a MIC value of 0.63 mg/mL to the S. hillii methanol extract. Quercetin-3-O-β-D-glucuronide and shikimic acid isolated from S. hillii methanol leaf extracts exhibited enhanced antibacterial effects against the tested bacteria with quercetin-3-O-β-D-glucuronide eliciting a MIC value of 0.78 µg/mL against E. faecalis. (4) Conclusions: S. hillii leaves are comprised of bioactive compounds that are bactericidal against several Gram-positive and Gram-negative bacteria.
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ID Code: | 236655 | ||||||
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Item Type: | Contribution to Journal (Journal Article) | ||||||
Refereed: | Yes | ||||||
ORCID iD: |
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Additional Information: | Funding Information: Funding: This research was funded by Salut Products Pty. Ltd. (formerly Health Focus Products Australia Pty. Ltd.), grant number 1400001143 | ||||||
Measurements or Duration: | 16 pages | ||||||
Keywords: | Antimicrobial, extract, Phytochemicals, Syncarpia hillii | ||||||
DOI: | 10.3390/plants11030283 | ||||||
ISSN: | 2223-7747 | ||||||
Pure ID: | 118250794 | ||||||
Divisions: | Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Clinical Sciences |
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Funding Information: | Funding: This research was funded by Salut Products Pty. Ltd. (formerly Health Focus Products Australia Pty. Ltd.), grant number 1400001143. | ||||||
Copyright Owner: | 2022 by the authors. | ||||||
Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||
Deposited On: | 30 Nov 2022 23:04 | ||||||
Last Modified: | 19 Jul 2024 17:43 |
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