Hybrid and synergistic drug strategies for biofilm eradication
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Description
The adhesion of bacteria to surfaces and their ability to form colonies called biofilms can cause significant health risks to humans and presents a major economic burden to society. Biofilms have been shown to be significantly less susceptible to traditional antimicrobials than their single cell bacterial counterparts. This makes in vivo eradication of biofilm difficult for most conventional antibiotics. The work presented in this thesis demonstrated the anti-biofilm potential of nitroxides and nitroxide-containing analogues which utilised existing antimicrobial agents such as peptides, amino acids, and quorum modulators in order to move away from the use of conventional antibiotics.
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| ID Code: | 237731 |
|---|---|
| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Fairfull-Smith, Kathryn, Boase, Nathan, & Totsika, Makrina |
| Keywords: | Antimicrobial Resistance, Bacterial Biofilms, Pseudomonas aeruginosa, Nitroxides, Antimicrobial Peptides, Quorum Sensing Modulation, Amino Acids, Molecular docking, CuAAC reaction, Acyl-homoserine lactones |
| DOI: | 10.5204/thesis.eprints.237731 |
| Pure ID: | 123823021 |
| Divisions: | Current > QUT Faculties and Divisions > Faculty of Science Current > Schools > School of Chemistry & Physics |
| Institution: | Queensland University of Technology |
| Deposited On: | 01 Feb 2023 05:01 |
| Last Modified: | 17 Jun 2024 06:26 |
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