Dietary Factors and Endometrial Cancer Risk: A Mendelian Randomization Study
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Description
Given the strong association between obesity and endometrial cancer risk, dietary factors may play an important role in the development of this cancer. However, observational studies of micro- and macronutrients and their role in endometrial cancer risk have been inconsistent. Clarifying these relationships are important to develop nutritional recommendations for cancer prevention. We performed two-sample Mendelian randomization (MR) to investigate the effects of circulating levels of 15 micronutrients (vitamin A (retinol), folate, vitamin B6, vitamin B12, vitamin C, vitamin D, vitamin E, β-carotene, calcium, copper, iron, magnesium, phosphorus, selenium, and zinc) as well as corrected relative macronutrient intake (protein, carbohydrate, sugar and fat) on risks of endometrial cancer and its subtypes (endometrioid and non-endometrioid histologies). Genetically predicted vitamin C levels were found to be strongly associated with endometrial cancer risk. There was some evidence that genetically predicted relative intake of macronutrients (carbohydrate, sugar and fat) affects endometrial cancer risk. No other significant association were observed. Conclusions: In summary, these findings suggest that vitamin C and macronutrients influence endometrial cancer risk but further investigation is required.
Impact and interest:
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| ID Code: | 241269 |
|---|---|
| Item Type: | Contribution to Journal (Journal Article) |
| Refereed: | Yes |
| Additional Information: | Funding: This research was funded by an Investigator grant from the National Health and Research Council of Australia, grant number APP1173170, and a project grant co-funded by Worldwide Cancer Research and Cancer Australia, grant number 22-0253. |
| Measurements or Duration: | 11 pages |
| Keywords: | Female, Humans, Mendelian Randomization Analysis, Vitamins, Ascorbic Acid, Endometrial Neoplasms/etiology, Sugars, Risk Factors |
| DOI: | 10.3390/nu15030603 |
| ISSN: | 2072-6643 |
| Pure ID: | 139167333 |
| Copyright Owner: | 2023 The Authors |
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| Deposited On: | 06 Jul 2023 05:44 |
| Last Modified: | 04 Aug 2024 20:59 |
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