The association between conjunctival and scleral thickness and ocular surface ultraviolet autofluorescence
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Description
Ultraviolet autofluorescence (UVAF) imaging is used to visualise ocular surface changes due to sunlight exposure and so is considered to be a biomarker for UV damage. The conjunctival and scleral thicknesses of participants with and without ocular surface UVAF were measured to examine the UVAF associated tissue thicknesses. The presence of UVAF on the ocular surface was associated with significant differences in tissue thickness including thinner conjunctival epitheliums and thicker scleras but predominantly thickening of the conjunctival stroma. Participants were also classified into four groups according to the presence and absence of UVAF on both the temporal and nasal conjunctivas. It was noted that for those that had only nasal UVAF, the temporal conjunctival stroma was significantly thicker even without the presence of UVAF. Some participants with temporal UVAF had signs of pinguecula observed with slit lamp examination and some had OCT SLO enface imaging darkening. These findings highlight the potential of techniques other than slit lamp examination, including tissue thickness measurement and UVAF photography, in the detection of early UV-related changes to the ocular surface.
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ID Code: | 241550 | ||||||||
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Item Type: | Contribution to Journal (Journal Article) | ||||||||
Refereed: | Yes | ||||||||
ORCID iD: |
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Additional Information: | Acknowledgements: This work was supported by Queensland University of Technology Women in STEMM writers retreat program. The authors thank Hoang An Tran for assistance with the UVAF area analysis. | ||||||||
Measurements or Duration: | 11 pages | ||||||||
DOI: | 10.1038/s41598-023-35062-2 | ||||||||
ISSN: | 2045-2322 | ||||||||
Pure ID: | 139772096 | ||||||||
Divisions: | Current > Research Centres > Centre for Biomedical Technologies Current > Research Centres > Centre for Vision and Eye Research Current > QUT Faculties and Divisions > Faculty of Engineering Current > QUT Faculties and Divisions > Faculty of Health |
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Funding Information: | This work was supported by Queensland University of Technology Women in STEMM writers retreat program. The authors thank Hoang An Tran for assistance with the UVAF area analysis. | ||||||||
Copyright Owner: | 2023 The Authors | ||||||||
Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||||
Deposited On: | 17 Jul 2023 23:36 | ||||||||
Last Modified: | 29 Feb 2024 13:41 |
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