Impact of genetic polymorphisms on the cancer risk, alternative splicing, and miRNA expression
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Description
The abnormal growth of cells in the prostate gland is what causes prostate cancer (PrCa). Short tandem repeats (STRs) consist of 1–6 bp motifs repeated in tandem. We analysed STR at the genome-wide level to find STR associated with PrCa, gene, and miRNA expression. Moreover, we investigated the effect of SNPs on alternative splicing (AS) and isomiR expression. We found PrCa-associated isomiR and splice variants. We developed a user-friendly web interface, isomiR-eQTL, that provides resources and comprehensive analysis outcomes on the genetic mechanisms of miRNA and isomiR regulation.
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| ID Code: | 241970 |
|---|---|
| Item Type: | QUT Thesis (PhD by Publication) |
| Supervisor: | Barrero, Roberto & Batra, Jyotsna |
| Keywords: | Short tandem repeats, isomiR, alternative splicing, prostate cancer, miRNA |
| DOI: | 10.5204/thesis.eprints.241970 |
| Pure ID: | 140688080 |
| Divisions: | Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 27 Jul 2023 06:00 |
| Last Modified: | 28 Jul 2023 05:02 |
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