Role of Iroquois homeobox 4 (IRX4) isoforms in prostate cancer
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Achala Vitharanage Thesis.pdf. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
The Iroquois (IRX) transcription factors belong to the homeobox protein family and have vital physiological functions in humans. Recent studies show that they are linked to human cancers, particularly Iroquois-class homeodomain protein 4 (IRX4) has been implicated in prostate cancer. In this thesis, four protein isoforms derived from alternative splicing of IRX4 were discovered in prostate cancer patients. They were found to have differential roles and mechanisms of action in prostate cancer pathogenesis. Additionally, the expression levels of identified IRX4 isoforms were evaluated in prostate cancer patient samples for their potential diagnostic and prognostic significance.
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| ID Code: | 242137 | ||
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| Item Type: | QUT Thesis (PhD by Publication) | ||
| Supervisor: | Batra, Jyotsna & Prasadam, Indira | ||
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| Keywords: | Alternative splicing, Iroquois homeobox 4 (IRX4), Chemoresistance, Prostate Cancer, Stem cells, Protein isoforms, Transcript variants, Androgens, IRX cluster, Transcription factor | ||
| DOI: | 10.5204/thesis.eprints.242137 | ||
| Pure ID: | 141445111 | ||
| Divisions: | Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
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| Institution: | Queensland University of Technology | ||
| Deposited On: | 04 Aug 2023 06:35 | ||
| Last Modified: | 04 Aug 2023 06:35 |
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