The functional role of a GWAS identified microRNA in prostate cancer

MicroRNAs (miRNAs) are small RNA species that act as master regulators in cancer by simultaneous regulation of multiple genes. In cancer cells, the lack of natural miRNA function and consequent uncontrolled oncogene expression leads to tumorigenesis. This study aimed to analyse the functional role of a specific miRNA, shorlisted via previous genetic association study. Stable overexpression cell lines harboring this miRNA were established, and its functional role was confirmed using cell proliferation, migration and invasion assays. Moreover, in vivo analyses confirmed the potential of our shortlisted miRNA for the "miRNA replacement therapy" to treat prostate cancer.