Exploring the Association between Hemochromatosis and Lower-Limb Venous Disease
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Description
OBJECTIVE: Chronic venous disease is a circulatory system dysfunction that has the potential to lead to venous leg ulceration. Although research on the influence of specific gene variants on chronic venous disease has been limited, a few studies have reported an association between hemochromatosis and chronic venous disease. However, no studies have looked at the prevalence of lower-limb venous disease and leg ulcers in people with hemochromatosis. This study aimed to review the existing literature for any association between venous disease and hemochromatosis and investigate the prevalence of venous disease and leg ulcers in people with hemochromatosis.
METHODS: Scoping systematic literature review and cross-sectional study surveying people with hemochromatosis.
RESULTS: This scoping systematic literature review included nine articles and indicated a link between hemochromatosis and venous disease/leg ulcers, although further studies are needed to support this link. Analysis of survey results from people with hemochromatosis found a 9.2% prevalence of leg ulcers in those with self-reported hemochromatosis, considerably higher than the 1% to 3% expected, suggesting that hemochromatosis gene variants may be associated with the pathogenesis of chronic venous disease and leg ulcers.
CONCLUSIONS: This is the first known study to complete a review of the literature regarding hemochromatosis and venous leg ulcers and document the association between hemochromatosis and venous disease/leg ulcers. There is a lack of research in this area and hence limited evidence to guide practice.
Impact and interest:
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ID Code: | 243742 | ||||||
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Item Type: | Contribution to Journal (Journal Article) | ||||||
Refereed: | Yes | ||||||
ORCID iD: |
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Measurements or Duration: | 8 pages | ||||||
Keywords: | Venous disease, Venous leg ulcers, hemochromatosis | ||||||
DOI: | 10.1097/ASW.0000000000000080 | ||||||
ISSN: | 1527-7941 | ||||||
Pure ID: | 146534558 | ||||||
Divisions: | Current > Research Centres > Centre for Healthcare Transformation Current > Research Centres > Centre for Genomics and Personalised Health Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences Current > Schools > School of Nursing |
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Funding Information: | The authors acknowledge the valuable contribution of Tony Moorhead and Dianne Prince from Haemochromatosis Australia. The authors have disclosed no financial relationships related to this article. Submitted December 2, 2022; accepted in revised form February 3, 2023. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal’s website (www.ASWCjournal.com). | ||||||
Copyright Owner: | 2023 Wolters Kluwer Health, Inc. | ||||||
Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||
Deposited On: | 18 Jan 2024 00:54 | ||||||
Last Modified: | 05 Aug 2024 03:35 |
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