Association between parenteral nutrition-containing intravenous lipid emulsion and bloodstream infections in patients with single-lumen central venous access: A secondary analysis of a randomized trial
Open access copy at publisher website
Description
<p>Background: Distinguishing primary bloodstream infections (BSIs) related to central venous access devices (CVADs) from those that occur through other mechanisms, such as a damaged mucosal barrier, is difficult. Methods: Secondary analysis was conducted on data from patients with CVADs that were collected for a large, randomized trial. Patients were divided into two groups: those who received parenteral nutrition (PN)–containing intravenous lipid emulsion (ILE) and those who did not have PN-containing ILE. This study investigated the influence of PN-containing ILE (ILE PN) on primary BSIs in patients with a CVAD. Results: Of the 807 patients, 180 (22%) received ILE PN. Most (627/807; 73%) were recruited from the hematology and hematopoietic stem cell transplant unit, followed by surgical (90/807; 11%), trauma and burns (61/807; 8%), medical (44/807; 5%), and oncology (23/807; 3%). When primary BSI was differentiated as a central line-associated BSI (CLABSI) or mucosal barrier injury laboratory-confirmed BSI (MBI-LCBI), the incidence of CLABSI was similar in the ILE PN and non–ILE PN groups (15/180 [8%] vs 57/627 [9%]; P = 0.88) and the incidence of MBI-LCBI was significantly different between groups (31/180 [17%] ILE PN vs 41/627 [7%] non–ILE PN; P < 0.01). Conclusion: Our data indicate that twice as many primary BSIs in ILE PN patients are due to MBIs than CVADs. It is important to consider the MBI-LCBI classification, as some CLABSI prevention efforts aimed at CVADs for the ILE PN population may be better directed to gastrointestinal tract protection interventions.</p>
Impact and interest:
Citation counts are sourced monthly from Scopus and Web of Science® citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.
| ID Code: | 245955 | ||||
|---|---|---|---|---|---|
| Item Type: | Contribution to Journal (Journal Article) | ||||
| Refereed: | Yes | ||||
| ORCID iD: |
|
||||
| Additional Information: | Acknowledgments: The authors thank the patients at the Royal Brisbane and Women's Hospital for participating in this research study. We appreciate the support from the nurses and medical officers in Cancer Care Services. Expert dietetics review was conducted by Dr. Sarah Andersen, dietitian nutritionist, and pharmacy review by Midori Nakagaki, pharmacist, at the Royal Brisbane and Women's Hospital. Nicole C. Gavin: This research was supported by a National Health and Medical Research Council–funded clinical trial (Intravascular Device Administration Sets: Replacement After Standard Versus Prolonged Use: The RSVP Trial APP1008428) and a research grant from the Cancer Nurses' Society of Australia. Nicole C. Gavin received a PhD scholarship from the National Health and Medical Research Council Centre of Research Excellence in Nursing Interventions in Hospital Patients at Griffith University, Brisbane, Australia, and the Royal Brisbane and Women's Hospital Foundation. Emily N. Larsen was a recipient of a Higher Degree Research Scholarship from the Australian Government Research Training Program between 2019 and 2020. Gabor Mihala was a recipient of a Higher Degree Research Scholarship from the Australian Government Research Training Program between 2019 and 2022. Samantha Keogh declares that her employer (QUT) has received monies on her behalf from BD Medical and ITL Biomedical for educational consultancies unrelated to this study. Claire Rickard reports investigator-initiated grants and consultancy payments made to her employers (Griffith University of University of Queensland) from 3M, BBraun, BD-Bard, Cardinal Health, Eloquest, and ITL Biomedical. Open access publishing facilitated by Griffith University, as part of the Wiley - Griffith University agreement via the Council of Australian University Librarians. | ||||
| Measurements or Duration: | 13 pages | ||||
| Keywords: | administration, intravenous, catheter-related infections, catheterization, central venous, central venous catheters, clinical nursing research, fat emulsion, intravenous, mucosal barrier injury laboratory-confirmed bloodstream infection, parenteral nutrition, vascular access devices | ||||
| DOI: | 10.1002/jpen.2530 | ||||
| ISSN: | 0148-6071 | ||||
| Pure ID: | 156596608 | ||||
| Divisions: | Current > Research Centres > Centre for Healthcare Transformation Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Nursing |
||||
| Funding Information: | Nicole C. Gavin received educational funding and honoraria from ICU Medical and Hospira. Emily N. Larsen's employer has received, on her behalf, an investigator‐initiated research grant from Cardinal Health (formerly Medtronic) and Eloquest Healthcare and an educational (conference) scholarship from Angiodynamics. Gillian Ray‐Barruel reports speaker fees provided to Griffith University by product manufacturers (3M, Becton Dickinson) and education providers (Ausmed, Wolters Kluwer, Continulus), unrelated to this project. Claire M. Rickard reports investigator‐initiated grants and consultancy payments made to her employer (Griffith University of University of Queensland) from 3M, BBraun, BD‐Bard, Cardinal Health, Eloquest, and ITL Biomedical. The authors thank the patients at the Royal Brisbane and Women's Hospital for participating in this research study. We appreciate the support from the nurses and medical officers in Cancer Care Services. Expert dietetics review was conducted by Dr. Sarah Andersen, dietitian nutritionist, and pharmacy review by Midori Nakagaki, pharmacist, at the Royal Brisbane and Women's Hospital. Nicole C. Gavin: This research was supported by a National Health and Medical Research Council–funded clinical trial (Intravascular Device Administration Sets: Replacement After Standard Versus Prolonged Use: The RSVP Trial APP1008428) and a research grant from the Cancer Nurses' Society of Australia. Nicole C. Gavin received a PhD scholarship from the National Health and Medical Research Council Centre of Research Excellence in Nursing Interventions in Hospital Patients at Griffith University, Brisbane, Australia, and the Royal Brisbane and Women's Hospital Foundation. Emily N. Larsen was a recipient of a Higher Degree Research Scholarship from the Australian Government Research Training Program between 2019 and 2020. Gabor Mihala was a recipient of a Higher Degree Research Scholarship from the Australian Government Research Training Program between 2019 and 2022. Samantha Keogh declares that her employer (QUT) has received monies on her behalf from BD Medical and ITL Biomedical for educational consultancies unrelated to this study. Claire Rickard reports investigator‐initiated grants and consultancy payments made to her employers (Griffith University of University of Queensland) from 3M, BBraun, BD‐Bard, Cardinal Health, Eloquest, and ITL Biomedical. Open access publishing facilitated by Griffith University, as part of the Wiley ‐ Griffith University agreement via the Council of Australian University Librarians. The authors thank the patients at the Royal Brisbane and Women's Hospital for participating in this research study. We appreciate the support from the nurses and medical officers in Cancer Care Services. Expert dietetics review was conducted by Dr. Sarah Andersen, dietitian nutritionist, and pharmacy review by Midori Nakagaki, pharmacist, at the Royal Brisbane and Women's Hospital. Nicole C. Gavin: This research was supported by a National Health and Medical Research Council–funded clinical trial (Intravascular Device Administration Sets: Replacement After Standard Versus Prolonged Use: The RSVP Trial APP1008428) and a research grant from the Cancer Nurses' Society of Australia. Nicole C. Gavin received a PhD scholarship from the National Health and Medical Research Council Centre of Research Excellence in Nursing Interventions in Hospital Patients at Griffith University, Brisbane, Australia, and the Royal Brisbane and Women's Hospital Foundation. Emily N. Larsen was a recipient of a Higher Degree Research Scholarship from the Australian Government Research Training Program between 2019 and 2020. Gabor Mihala was a recipient of a Higher Degree Research Scholarship from the Australian Government Research Training Program between 2019 and 2022. Samantha Keogh declares that her employer (QUT) has received monies on her behalf from BD Medical and ITL Biomedical for educational consultancies unrelated to this study. Claire Rickard reports investigator-initiated grants and consultancy payments made to her employers (Griffith University of University of Queensland) from 3M, BBraun, BD-Bard, Cardinal Health, Eloquest, and ITL Biomedical. Open access publishing facilitated by Griffith University, as part of the Wiley - Griffith University agreement via the Council of Australian University Librarians. | ||||
| Funding: | |||||
| Copyright Owner: | 2023 The Authors | ||||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||
| Deposited On: | 30 Jan 2024 05:59 | ||||
| Last Modified: | 30 Apr 2024 02:09 |
Export: EndNote | Dublin Core | BibTeX
Repository Staff Only: item control page
CORE (COnnecting REpositories)
CORE (COnnecting REpositories)