Addressing protein localization within the nucleus
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Description
Bridging the gap between the number of gene sequences in databases and the number of gene products that have been functionally characterized in any way is a major challenge for biology. A key characteristic of proteins, which can begin to elucidate their possible functions, is their subcellular location. A number of experimental approaches can reveal the subcellular localization of proteins in mammalian cells. However, genome databases now contain predicted sequences for a large number of potentially novel proteins that have yet to be studied in any way, let alone have their subcellular localization determined. Here we ask whether using bioinformatics tools to analyse the sequence of proteins whose subnuclear localizations have been determined can reveal characteristics or signatures that might allow us to predict localization for novel protein sequences.
Impact and interest:
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| ID Code: | 248059 | ||
|---|---|---|---|
| Item Type: | Contribution to Journal (Review article) | ||
| Refereed: | Yes | ||
| ORCID iD: |
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| Additional Information: | Acknowledgements: We thank Paul McLaughlin (University of Edinburgh) for useful discussions on protein architecture and Colin Semple for reading the manuscript. Most of all, we thank Rachel Farrall for constructing the Nuclear Protein Database. H.S. is supported by a fellowship from the AICR. W.A.B. is a Centennial Fellow of the James S.McDonnell Foundation. | ||
| Measurements or Duration: | 7 pages | ||
| Keywords: | Bioinformatics, Nuclear organization, Nucleus, Protein sequence, Protein structure | ||
| DOI: | 10.1093/emboj/21.6.1248 | ||
| ISSN: | 0261-4189 | ||
| Pure ID: | 167056681 | ||
| Copyright Owner: | 2002 European Molecular Biology Organization | ||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||
| Deposited On: | 16 Apr 2024 23:40 | ||
| Last Modified: | 23 Apr 2024 07:01 |
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