Design, synthesis and testing of oxazolidinone antimicrobials that target biofilms
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Audrey Ndukwe Thesis. Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
Antibiotics are the treatment of choice for bacterial infections, but their loss of effectiveness presents a global public health issue. The threat from antimicrobial resistance not only lies in single-celled bacteria but in communities of bacteria that aggregate and form biofilms. Antibiotic development has primarily focused on single-celled bacteria with limited consideration of the role of biofilms on disease progression. Bacteria in biofilms are up to 1000 times more resistant to antibiotics than their single-celled counterparts causing relapsing infections that are challenging to treat. This thesis investigates strategies to develop the oxazolidinone antibiotic class as biofilm eradication agents using nitroxides.
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| ID Code: | 248139 | ||
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| Item Type: | QUT Thesis (PhD by Publication) | ||
| Supervisor: | Fairfull-Smith, Kathryn, Boase, Nathan, & Totsika, Makrina | ||
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| Keywords: | Anti-biofilm, Antibiotics, Antimicrobial resistance, Bacterial biofilms, Biofilm eradication agents, Methicillin resistant Staphylococcus aureus, Minimum Biofilm Eradication Concentration, Linezolid, Oxazolidinone, Nitroxide | ||
| DOI: | 10.5204/thesis.eprints.248139 | ||
| Pure ID: | 167029330 | ||
| Divisions: | Current > QUT Faculties and Divisions > Faculty of Science Current > Schools > School of Chemistry & Physics |
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| Institution: | Queensland University of Technology | ||
| Deposited On: | 18 Apr 2024 07:05 | ||
| Last Modified: | 18 Apr 2024 07:08 |
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