Total fraction of drug released from diffusion-controlled delivery systems with binding reactions
Open access copy at publisher website
Description
In diffusion-controlled drug delivery, it is possible for drug molecules to bind to the carrier material and never be released. A common way to incorporate this phenomenon into the governing mechanistic model is to include an irreversible first-order reaction term, where drug molecules become permanently immobilized once bound. For diffusion-only models, all the drug initially loaded into the device is released, while for reaction–diffusion models only a fraction of the drug is ultimately released. In this short paper, we show how to calculate this fraction for several common diffusion-controlled delivery systems. Easy-to-evaluate analytical expressions for the fraction of drug released are developed for monolithic and core–shell systems of slab, cylinder or sphere geometry. The developed formulas provide analytical insight into the effect that system parameters (e.g. diffusivity, binding rate, core radius) have on the total fraction of drug released, which may be helpful for practitioners designing drug delivery systems.
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ID Code: | 248839 | ||
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Item Type: | Contribution to Journal (Journal Article) | ||
Refereed: | Yes | ||
ORCID iD: |
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Measurements or Duration: | 7 pages | ||
Keywords: | drug delivery, binding, reaction-diffusion, core-shell, release profile | ||
DOI: | 10.1016/j.ijheatmasstransfer.2024.125712 | ||
ISSN: | 0017-9310 | ||
Pure ID: | 169956685 | ||
Divisions: | Current > QUT Faculties and Divisions > Faculty of Science Current > Schools > School of Mathematical Sciences |
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Copyright Owner: | 2024 The Authors | ||
Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||
Deposited On: | 31 May 2024 02:52 | ||
Last Modified: | 06 Jun 2024 18:00 |
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