Investigating the role of mitochondrial energy rewiring throughout prostate cancer progression
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Description
Prostate cancer is the most commonly diagnosed non-cutaneous cancer in men. Despite effective first-line therapies, approximately 30% of patients will recur with advanced disease, highlighting an unmet clinical burden. This project investigated the role of mitochondrial plasticity within the progression of prostate cancer and within the onset of therapeutic resistance to commonly prescribed androgen targeted medications. As a result of the work performed in this thesis, we have identified a key metabolic pathway driving advanced prostate cancer progression and propose novel therapeutic strategies which inhibits an enzyme critical to this molecular adaption.
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| ID Code: | 248849 |
|---|---|
| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Gunter, Jennifer, Nelson, Colleen, & Philp, Lisa |
| Keywords: | Prostate Cancer, Metabolism, Androgen Targeted Therapies, Branched-Chain Amino Acids, Valine Catabolism, 3-Hydroxyisobutyryl-CoA Hydrolase, Oncology, Molecular Biology, Biochemistry, Fluorescence Microscopy |
| DOI: | 10.5204/thesis.eprints.248849 |
| Pure ID: | 132830903 |
| Divisions: | Current > QUT Faculties and Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 31 May 2024 06:09 |
| Last Modified: | 28 Jun 2024 04:53 |
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