Pulsed field gradient nuclear magnetic resonance as a tool for studying drug delivery systems

Momot, Konstantin I. & Kuchel, Philip W. (2003) Pulsed field gradient nuclear magnetic resonance as a tool for studying drug delivery systems. Concepts in Magnetic Resonance. Part A, 19A(2), pp. 51-64.

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Pulsed field gradient (PFG) nuclear magnetic resonance (NMR) is a versatile method for studying molecular transport and exchange in solution. Stejskal-Tanner diffusion plots can be used to distinguish between chemical species even in the absence of chemical shift or T1 resolution, provided that certain conditions are satisfied. This can be used advantageously in colloidal drug delivery systems containing two drug populations, free and bound, which often differ only by their diffusion coefficients. We discuss the conditions required for the resolution of the two pools in Stejskal-Tanner plots, as well as the effects of chemical exchange. We also present two practical examples of this analysis: surfactant micelles containing the general anesthetic propofol and lipid/water liquid crystalline mesophase vehicles (cubosomes).

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46 citations in Scopus
47 citations in Web of Science®
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ID Code: 2672
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Nuclear magnetic resonance, nonionic surfactant micelles, monoolein cubosomes and vesicles, pulsed field gradient spin, echo (PGSE) NMR spectroscopy, diffusion, molecular association and chemical exchange, drug delivery vehicles
DOI: 10.1002/cmr.a.10092
ISSN: 1546-6086
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2003 John Wiley & Sons
Copyright Statement: The definite version is available on publication at www3.interscience.wiley.com
Deposited On: 30 Nov 2005 00:00
Last Modified: 06 Jul 2015 04:36

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