Human tear responses to alkali

Hill, Richard M. & Carney, Leo G. (1980) Human tear responses to alkali. Investigative Ophthalmology and Visual Science, 19(2), pp. 207-210.


With the use of a closed-chamber microelectrode system, the buffering capacities of over 100 tear samples were measured in response to alkali challenge of several strengths. Although distinctive variations were found among the seven subjects studied, a substantially greater buffer capacity was consistently noted in all their tear responses to pH conditions of near 10 and above. These results are consistent with the early observations of Friedenwald, who demonstrated the buffering capacity of corneal tissue when challenged in this higher pH range, and may here be due to the onset of protein denaturation in the tears.

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7 citations in Scopus
9 citations in Web of Science®
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ID Code: 3161
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details:
Additional URLs:
Keywords: Alkalies/, pharmacology, Tears/, drug effects, Adult, Buffers, Female, Humans, Hydrogen, Ion Concentration, Male, Research Support, U, S, Gov't, P, H, S, Sodium Hydroxide/pharmacology, Tears/analysis
ISSN: 0146-0404
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1980 Association for Research in Vision and Ophthalmology
Deposited On: 30 Jan 2006 00:00
Last Modified: 15 Jan 2009 06:54

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