Intersubject variability in corneal swelling response to anoxia

Efron, Nathan (1986) Intersubject variability in corneal swelling response to anoxia. Acta Ophthalmologica Scandinavica, 64(3), pp. 302-305.


A controlled, double-masked, randomized experiment was conducted on 9 human subjects, to determine whether there is an intersubject difference in the corneal swelling response to anoxia. A statistically significant intersubject variability was observed (P less than 0.001), with oedema ranging from a mean of 3.6% to 7.3% following 3 h exposure to humidified nitrogen gas (anoxia). This result supports the hypothesis of previous workers that the intersubject difference in the corneal oedema response to a thick HEMA "stress lens" is due to oxygen deprivation and not some other physiological variable resulting from lens wear.

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20 citations in Scopus
10 citations in Web of Science®
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ID Code: 3350
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details:
Additional URLs:
Keywords: Anoxia/, physiopathology, Corneal Diseases/, etiology, Edema/, etiology, Adult, Anoxia/chemically induced, Clinical Trials, Contact Lenses/adverse effects, Double, Blind Method, Female, Humans, Male, Nitrogen, Random Allocation, Species Specificity
ISSN: 1395-3907
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1986 Blackwell Publishing
Deposited On: 08 Feb 2006 00:00
Last Modified: 15 Jan 2009 06:56

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