Corneal thickness changes following sleep and overnight contact lens wear in the primate (Macaca fascicularis)

Madigan, Michele C., Gillard-Crewther, Sheila, Kiely, Patricia M., Crewther, David P., Brennan, Noel A., Efron, Nathan, & Holden, Brien A. (1987) Corneal thickness changes following sleep and overnight contact lens wear in the primate (Macaca fascicularis). Current eye research, 6(6), pp. 809-815.


Corneal thickness was monitored on seven cynomolgus monkeys (Macaca fascicularis) over a 76 hour period. During this time, corneal thickness measurements were also made on six monkeys after overnight wear of a hydrogel contact lens in one eye. Mean corneal thickness was 417 +/- 12 microns. An overall diurnal variation of 16 +/- 5 microns (3.8 +/- 1.2%) was found. During the first half hour after waking, corneal thickness changes ranged from -9 microns to +14 microns. After overnight contact lens wear, the cornea had swelled an average of 42 +/- 24 microns (9.1 +/- 4.8%). Following lens removal, the cornea returned to normal thickness within approximately 90 minutes. These results are similar to those found in humans and indicate that with respect to contact lens induced corneal thickness changes, the cynomolgus monkey is a suitable model for the physiological response to contact lens wear.

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13 citations in Scopus
10 citations in Web of Science®
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ID Code: 3356
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details:
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Keywords: Contact Lenses, Cornea/, anatomy & histology, Sleep/, physiology, Animals, Circadian Rhythm, Female, Male, Research Support, Non, U, S, Gov't
ISSN: 0271-3683
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 1987 Taylor & Francis
Deposited On: 17 Feb 2006 00:00
Last Modified: 10 Aug 2011 14:42

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