The effect of a beta-adrenoceptor antagonist on accommodative adaptation in Hong Kong children

Chen, Jennifer C., Schmid, Katrina L., Brown, Brian, & Edwards, Marion H. (2005) The effect of a beta-adrenoceptor antagonist on accommodative adaptation in Hong Kong children. Current Eye Research, 30(3), pp. 179-188.

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PURPOSE: Increased susceptibility to nearwork-induced accommodative adaptation has been suggested as a risk factor for myopia development. We investigated whether accommodative adaptation may explain in part the high prevalence of myopia in Hong Kong children and examined the effect of beta-antagonism with topical timolol maleate on accommodative adaptation.Methods: Thirty children (10 emmetropes and 20 myopes) aged between 8 and 12 years were recruited. Tonic accommodation was measured before and after 5 min of video game-playing using an open-field Shin-Nippon autorefractor. Measurements were repeated 30 min after timolol instillation. RESULTS: Children with progressing myopia demonstrated accommodative adaptation following the near task, whereas stable myopes showed counter-adaptive, hyperopic accommodative changes. Timolol increased the magnitude of accommodative adaptation in the stable myopes but had little effect on responses of the progressing myopes or emmetropes. CONCLUSIONS: Neuropharmacological modulation of the accommodative system may have a possible etiological role in the progression of myopia.

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2 citations in Scopus
3 citations in Web of Science®
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ID Code: 4273
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details:
Keywords: Accommodation, Ocular/, drug effects, Adaptation, Ocular/, drug effects, Adrenergic beta, Antagonists/, pharmacology, Timolol/, pharmacology, Child, Female, Hong Kong/ethnology, Humans, Male, Myopia/ethnology, Myopia/physiopathology
DOI: 10.1080/02713680490908571
ISSN: 1460-2202
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2005 Taylor & Francis
Copyright Statement: First published in Current Eye Research 30(3):pp. 179-188.
Deposited On: 22 Jun 2006 00:00
Last Modified: 29 Feb 2012 13:15

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