Bone and prostate cancer cell interactions in metastatic prostate cancer

Vela, Ian, Gregory, Laura S., Gardiner, Edith M., Clements, Judith A., & Nicol, David L. (2007) Bone and prostate cancer cell interactions in metastatic prostate cancer. BJU International, 99(4), pp. 735-742.


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The interplay in prostate cancer bone metastases between the 'seed' (the prostate cancer cells) and the 'soil' (the bone microenvironment) has been increasingly recognized as integral to the remarkable tropism for bone shown by prostate cancer. Increasing research into this area is elucidating the mechanisms involved in this complex 'cross-talk'. Recent developments, including the use of bisphosphonates in metastatic disease, highlight the important role of bone cells in the development and progression of metastatic prostate cancer. We review the current reports emphasising these possible mechanisms and indicating possible factors for future treatment directions.

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19 citations in Scopus
11 citations in Web of Science®
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ID Code: 6125
Item Type: Journal Article
Refereed: Yes
Keywords: bone, prostate, cancer, metastasis, cross, talk
DOI: 10.1111/j.1464-410X.2006.06670.x
ISSN: 1464-4096
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2007 Blackwell Publishing
Copyright Statement: The definitive version is available at
Deposited On: 15 Feb 2007 00:00
Last Modified: 29 Feb 2012 13:27

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