Spatial Tumor-Immune Modeling

de Pillis, Lisette G., Mallet, Daniel G., & Radunskaya, Ami E. (2006) Spatial Tumor-Immune Modeling. Computational and Mathematical Methods in Medicine, 7(2-3), pp. 159-176.

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In this paper, we carry out an examination of four mechanisms that can potentially lead to changing morphologies in a growing tumor: variations in nutrient consumption rates, cellular adhesion, excessive consumption of nutrients by tumor cells and immune cell interactions with the tumor. We present numerical simulations using a hybrid PDE-cellular automata (CA) model demonstrating the effects of each mechanism before discussing hypotheses about the contribution of each mechanism to morphology change.

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28 citations in Scopus
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ID Code: 6408
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information please refer to the publisher's website (link above) or contact the author:
Keywords: Tumor, Immune, Cellular automata, Cellular adhesion, Tumor morphology
DOI: 10.1080/10273660600968978
ISSN: 1748-6718
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > APPLIED MATHEMATICS (010200) > Biological Mathematics (010202)
Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000)
Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > OTHER MATHEMATICAL SCIENCES (019900)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2006 Taylor & Francis
Copyright Statement: First published in Computational and Mathematical Methods in Medicine 7(2-3):pp. 159-176.
Deposited On: 09 Mar 2007 00:00
Last Modified: 29 Feb 2012 13:21

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