A recurrent network in the lateral amygdala : a mechanism for coincidence detection
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Description
Synaptic changes at sensory inputs to the dorsal nucleus of the lateral amygdala (LAd) play a key role in the acquisition and storage of associative fear memory. However, neither the temporal nor spatial architecture of the LAd network response to sensory signals is understood. We developed a method for the elucidation of network behavior. Using this approach, temporally patterned polysynaptic recurrent network responses were found in LAd (intra-LA), both in vitro and in vivo, in response to activation of thalamic sensory afferents. Potentiation of thalamic afferents resulted in a depression of intra-LA synaptic activity, indicating a homeostatic response to changes in synaptic strength within the LAd network. Additionally, the latencies of thalamic afferent triggered recurrent network activity within the LAd overlap with known later occurring cortical afferent latencies. Thus, this recurrent network may facilitate temporal coincidence of sensory afferents within LAd during associative learning.
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ID Code: | 67963 |
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Item Type: | Contribution to Journal (Journal Article) |
Refereed: | Yes |
Measurements or Duration: | 19 pages |
Keywords: | Amygdala, Autoassociative, Fear Memory, Feedback, Hopfield, LTD, Polysynaptic, Reverberation, Synapse |
DOI: | 10.3389/neuro.04.003.2008 |
ISSN: | 1662-5110 |
Pure ID: | 33649817 |
Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation Current > Schools > School of Psychology & Counselling |
Copyright Owner: | Copyright 2008 Johnson, Hou, Ponce-Alvarez, Gribelyuk, Alphs, Albert, Brown, LeDoux and Doyère |
Copyright Statement: | This document is protected by copyright and was first published by Frontiers. All rights reserved. It is reproduced with permission. |
Deposited On: | 03 Mar 2014 01:07 |
Last Modified: | 24 Jun 2024 17:45 |
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