Novel sequential methods in dose-finding designs : extensions of the continual reassessment method
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Darsy Darssan Thesis
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Description
Dose-finding trials are a form of clinical data collection process in which the primary objective is to estimate an optimum dose of an investigational new drug when given to a patient. This thesis develops and explores three novel dose-finding design methodologies. All design methodologies presented in this thesis are pragmatic. They use statistical models, incorporate clinicians' prior knowledge efficiently, and prematurely stop a trial for safety or futility reasons. Designing actual dose-finding trials using these methodologies will minimize practical difficulties, improve efficiency of dose estimation, be flexible to stop early and reduce possible patient discomfort or harm.
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| ID Code: | 69374 |
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| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Pettitt, Tony & Thompson, Helen |
| Keywords: | Continual Reassessment Method, Global cross-ratio, Adverse event relatedness, EM Algorithm, Prior data |
| Divisions: | Past > Institutes > Institute of Health and Biomedical Innovation Past > QUT Faculties & Divisions > Science & Engineering Faculty Current > Schools > School of Mathematical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 15 May 2014 05:17 |
| Last Modified: | 13 Sep 2017 14:42 |
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