Characterisation of cytokine response to Chlamydia pecorum infection in the koala, Phascolarctos cinereus
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Marina Mathew Thesis
(PDF 4MB)
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Description
This thesis aimed at identifying cytokine markers associated with chlamydial infection and disease in koalas which is facing many threats to its survival, Chlamydia pecorum infections being a major one. To identify immunological markers associated with chlamydial infection and disease in koalas, key cytokines such as TNF alpha, IL10, IFN gamma and IL17A were cloned and sequenced and subsequently developed Quantitative Real Time PCR (qrtPCR) assays. The thesis provides preliminary data on the role of these cytokines in koala chlamydial disease and further longitudinal studies are required to confirm the role played by cytokines in pathology and protection against C. pecorum infection in the koala.
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| ID Code: | 78617 |
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| Item Type: | QUT Thesis (PhD by Publication) |
| Supervisor: | Timms, Peter, Beagley, Kenneth, & Polkinghorne, Adam |
| Keywords: | Chlamydia pecorum, Koala, Phascolarctos cinereus, IFNγ, Cytokines, quantitative real time PCR, TNFα, IL17A, IL10 |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 09 Feb 2015 02:44 |
| Last Modified: | 15 Sep 2017 14:42 |
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