Identification and characterization of novel proteolytic interactions of prostate cancer-expressed kallikrein-related peptidases, type II transmembrane serine proteases and matrix metalloproteinases
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Janet Reid Thesis (PDF 7MB) |
Description
This study investigated interactions of protein-cleaving enzymes (or proteases) that promote prostate cancer progression. It provides the first evidence of a novel regulatory network of protease activity at the surface of cells. The proteases kallikrein-related peptidases 4 and 14, and matrix metalloproteinases 3 and 9 are cleaved at the cell surface by the cell surface proteases hepsin and TMPRSS2. These cleavage events potentially regulate activation of downstream targets of kallikrein 4 and 14 such as cell surface signalling via the protease-activated receptors (PARs) and cell growth-promoting factors such as hepatocyte-growth factor.
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| ID Code: | 81594 |
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| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Hooper, John & Clements, Judith |
| Keywords: | Kallikrein-Related Peptidase (KLK), Type II Transmembrane Serine Protease (TTSP), Matrix Metalloproteinase (MMP), Protease-Activated Receptor (PAR), Hepatocyte Growth Factor Activator Inhibitor-1, Hepatocyte Growth Factor (HGF), Calcium Signalling, Activity Based Probe (ABP), Cell Surface, Proteolytic Cascade |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 26 Feb 2015 06:53 |
| Last Modified: | 21 Sep 2017 14:43 |
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