Modeling the Dependence Between the Number of Trials and the Success Probability in Binary Trials

A model for binary trials based on a bivariate generalization of the Poisson process for both the number of successes and number of trials with the transition rates dependent on the accumulating numbers of successes and trials is used to reanalyze some recently published data of Zhu, Eickhoff, and Kaiser (2003, Biometrics59, 955–961). This modeling admits alternative distributions for the numbers of trials and the numbers of successes conditional on the number of trials which generalize the Poisson and binomial distributions, without some of the restrictions apparent in the beta-binomial-Poisson mixed modeling of Zhu et al. (2003). Some quite marked differences between the results of this analysis and those described in Zhu et al. (2003) are apparent.