Image: Neuronal, physiological and brain-behavioural abnormalities in opiate-addicted individuals
Description
Illustrated are the group level dorsal anterior cingulate cortex (dACC) BOLD activation maps and the spatial location of the volume localized proton-MRS (superimposed in blue) on a sagittaly oriented structural MR image (MNI, Talairach brain) for healthy controls (panel a) and opiate-dependent subject (panel b). While both groups activated the dACC to comparable levels, the opiate-using group (i) failed to show the expected correlations between dACC physiological activity and behavioural measures of control (that is, response errors) shown by the control group, (ii) had significantly increased task-related activation of fronto-parietal and cerebellar regions to achieve a comparable level of behavioural control as healthy controls and (iii) exhibited significantly reduced concentrations of N-acetylaspartate (NAA) and glutamate/glutamine (Glx) within the dACC (panel c; horizontal bars represent mean values). Taken together, these findings suggest that neuronal abnormalities and a breakdown of normal brain–behaviour relationships within the dACC of opiate addicted individuals may result in the recruitment of a compensatory network of brain regions in situations requiring behavioural control. For more information on this topic, please see the article by Yucel et al. on pp 691–702.
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ID Code: | 8367 | ||
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Item Type: | Contribution to Journal (Journal Article) | ||
Refereed: | No | ||
ORCID iD: |
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Measurements or Duration: | 1 pages | ||
Keywords: | Cingulate, Dependence, Functional, Heroin, Metabolie | ||
DOI: | 10.1038/sj.mp.4002033 | ||
ISSN: | 1359-4184 | ||
Pure ID: | 33737071 | ||
Divisions: | Past > QUT Faculties & Divisions > Faculty of Science and Technology Past > Institutes > Institute of Health and Biomedical Innovation Past > QUT Faculties & Divisions > Science & Engineering Faculty Current > Research Centres > Australian Research Centre for Aerospace Automation |
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Copyright Owner: | Consult author(s) regarding copyright matters | ||
Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||
Deposited On: | 02 Jul 2007 00:00 | ||
Last Modified: | 03 Mar 2024 15:19 |
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