Body mass index-related human adipocyte agouti expression is sex-specific but not depot-specific

Voisey, Joanne, Imbeault, Pascal, Hutley, Louise J., Prins, John B., & Van Daal, Angela M. (2002) Body mass index-related human adipocyte agouti expression is sex-specific but not depot-specific. Obesity Research, 10(6), pp. 447-452.


OBJECTIVE: To determine if human adipocyte agouti signal protein (ASIP) mRNA expression is associated with obesity and is gender and/or depot specific. RESEARCH METHODS AND PROCEDURES: Subjects included 8 men (64 +/- 3 years) and 14 women (56 +/- 15 years) undergoing elective abdominal surgery. ASIP mRNA levels in isolated omental and subcutaneous abdominal adipocytes were measured by quantitative reverse transcription polymerase chain reaction. RESULTS: No significant depot difference was observed between genders; ASIP mRNA levels of omental and subcutaneous abdominal adipocytes were pooled for this analysis. BMI and ASIP gene expression were negatively correlated in men (rho = -0.70; p < 0.05), whereas a positive relationship was observed in women (rho = 0.48; p < 0.05). No significant difference was observed in age, body weight, body mass index (BMI), and waist circumference between groups. Hip circumference was significantly higher in women than in men (p < 0.05). Also, no significant difference in ASIP mRNA expression was observed between men and women, regardless of the fat depot. DISCUSSION: These results show that men and women of similar age and BMI present similar ASIP mRNA levels in omental and subcutaneous abdominal adipocytes. However, a sexual dimorphism exists in the relationship between ASIP expression and BMI. If ASIP is involved in appetite regulation or energy homeostasis in humans, this observation may contribute to the recognized differences in these parameters between men and women.

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12 citations in Scopus
11 citations in Web of Science®
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ID Code: 8466
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see hypertext link) or contact the author.
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Keywords: agouti expression, quantitative polymerase chain reaction, energy homeostasis
ISSN: 1071-7323
Divisions: Current > Research Centres > CRC for Diagnostics
Past > QUT Faculties & Divisions > Faculty of Science and Technology
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2002 The North American Association for the Study of Obesity
Deposited On: 06 Jul 2007 00:00
Last Modified: 09 Jun 2010 12:42

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