Immunological Changes after Cancer Treatment and Participation in an Exercise Program

Hayes, Sandra C., Rowbottom, David W., Davies, Peter S., Parker, Tony W., & Bashford, John (2003) Immunological Changes after Cancer Treatment and Participation in an Exercise Program. Medicine and Science in Sports and Exercise, 35(1), pp. 2-9.

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Purpose: The purpose of this investigation was to evaluate the impact of undertaking peripheral blood stem cell transplantation (PBST) on T-cell number and function, and to determine the role of a mixed type, moderate intensity exercise program in facilitating the recovery of T-cell number and function.

Methods: Immunological measures of white blood cell, lymphocyte, CD3+, CD4+, and CD8+ counts, and CD3+ cell function were assessed pretransplant (PI), immediately posttransplant (PII), and 1 month (I1), 2 months (I2) and 3 months (PIII) posttransplant. After PII, 12 patients were divided equally into a control group (CG) or exercise intervention group (EG).

Results: Lower total T-cell, helper T-cell, and suppressor T-cell counts (P < 0.01), as well as lower T-cell function (P < 0.01), when compared with normative data, were found at PI. More specifically, 88% of the group had CD3+, CD4+, and CD8+ counts that were more than 40%, 20%, and 50% below normal at PI, respectively. Undertaking a PBST caused further adverse changes to the total leukocyte, lymphocyte, CD3+, CD4+ and CD8+ count, and the helper/suppressor ratio. Although CD8+ counts had returned to normal by PIII, CD3+, CD4+, and the CD4+/CD8+ ratio remained significantly lower than normative data (P < 0.01), with 66%, 100%, and 100% of the subject group reporting counts and ratios, respectively, below the normal range.

Conclusion: The PBST patients were immunocompromised before undertaking the transplant, and the transplant procedure imposed further adverse changes to the leukocyte and lymphocyte counts. The leukocyte and CD8+ counts returned to normal within 3 months posttransplant; however, the other immunological parameters assessed demonstrated a delayed recovery. Although participation in the exercise program did not facilitate a faster immune cell recovery, neither did the exercise program hinder or delay recovery.

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39 citations in Scopus
34 citations in Web of Science®
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ID Code: 9242
Item Type: Journal Article
Refereed: Yes
Additional URLs:
DOI: 10.1249/01.MSS.0000043283.45753.E7
ISSN: 1530-0315
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Oncology and Carcinogenesis not elsewhere classified (111299)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > HUMAN MOVEMENT AND SPORTS SCIENCE (110600) > Exercise Physiology (110602)
Divisions: Past > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2003 Lippincott Williams & Wilkins
Copyright Statement: This is the author-version of the work. The final, definitive version of this article has been published in the Journal, < Medicine & Science in Sports & Exercise 35(1):pp. 2-9, 2003 © < Lippincott, Williams & Wilkins.
Deposited On: 31 Aug 2007 00:00
Last Modified: 27 Jun 2012 21:59

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