Cleavage and nuclear translocation of FGR2B in an endometrial cancer cell line
Mangan, Alain A. (2016) Cleavage and nuclear translocation of FGR2B in an endometrial cancer cell line. Masters by Research thesis, Queensland University of Technology.
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Alain Mangan Thesis (PDF 4MB) |
Description
This project was focused on characterising the cleavage and possible nuclear translocation of FGFR2 in endometrial cancer cells. Several new cancer drugs targeting FGFR2 are in clinical trials and yet little is known about this receptor. In this project, we utilized a tagged FGFR2 and detected a novel form of receptor cleavage but no nuclear entry. A protein called ADAM9 had been shown to cleave FGFR2 in bone cells, but this project went on to rule out ADAM9 as involved in FGFR2 cleavage in cancer cells. Ongoing studies are needed to understand the importance of this receptor cleavage in cancer.
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| ID Code: | 92430 |
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| Item Type: | QUT Thesis (Masters by Research) |
| Supervisor: | Pollock, Pamela, Stehbens, Samantha, & Stephenson, Sally-Anne |
| Keywords: | Fibroblast Growth Factor Receptor 2, Receptor cleavage, Nuclear translocation, ADAM 9, Endometrial cancer |
| DOI: | 10.5204/thesis.eprints.92430 |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation |
| Institution: | Queensland University of Technology |
| Deposited On: | 23 Jul 2018 09:18 |
| Last Modified: | 16 Jan 2025 00:51 |
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