Prohibitin 3' untranslated region polymorphism and breast cancer risk in Australian women

Spurdle, Amanda B., Hopper, John L., Chen, Xiaoqing, McCredie, Margaret R.E., Giles, Graham G., Newman, Beth M., & Chenevix-Trench, Georgia (2002) Prohibitin 3' untranslated region polymorphism and breast cancer risk in Australian women. The Lancet, 360(9337), pp. 925-926.

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A C to T transition within the 3' untranslated region of the prohibitin gene alters mRNA function, and an association between the T allele and an increased risk of breast cancer has been reported in North American women, specifically in those aged under 50 years with a first-degree family history of breast cancer. We did a population-based case-control study to assess whether this association existed in Australian women. We did not note such an association in our sample of 1446 patients and 786 controls (odds ratio 0.96, 95% CI 0.80-1.16; p=0.7), or in subgroups defined by age or family history, or both. Hence, our results do not lend support to the hypothesis that this polymorphism contributes to risk of breast cancer.

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21 citations in Scopus
19 citations in Web of Science®
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ID Code: 9259
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal's website (see hypertext link) or contact the author.
DOI: 10.1016/S0140-6736(02)11043-9
ISSN: 0140-6736
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Oncology and Carcinogenesis not elsewhere classified (111299)
Divisions: Past > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2002 Elsevier
Deposited On: 31 Aug 2007 00:00
Last Modified: 10 Aug 2011 16:01

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