Epigenetics underpinning DNA damage repair
Description
Epigenetics is the study of heritable changes in gene expression that are not the result of genetic alterations. These changes include DNA methylation, histone modifications, or indeed microRNA expression. Chromatin is a tightly compacted DNA–protein complex that allows approximately two meters of DNA to be packaged inside a cell, only a few micrometers across. Although the resulting DNA structure is very stable, it is not very amiable to DNA-dependent processes, so mechanisms have to exist to allow processes such as transcription, replication, and DNA repair to occur. This chapter will look at how a cell responds to and deals with genomic instability at the epigenetic level and highlight how critical chromatin remodeling is for correct DNA repair and cell survival following DNA damage. This chapter will initially look at the DNA repair pathways that function in human cells and then at how the repair of DNA damage is controlled by epigenetics.
Impact and interest:
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ID Code: | 95334 | ||||||
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Item Type: | Chapter in Book, Report or Conference volume (Chapter) | ||||||
ORCID iD: |
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Measurements or Duration: | 18 pages | ||||||
Keywords: | Base excision repair, DNA damage, Double-strand break repair, Epigenetics, Homologous recombination, Mismatch repair, Nonhomologous end joining, Nucleotide excision repair | ||||||
DOI: | 10.1016/B978-0-12-800206-3.00025-2 | ||||||
ISBN: | 978-0-12-800206-3 | ||||||
Pure ID: | 32809605 | ||||||
Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation |
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Copyright Owner: | Consult author(s) regarding copyright matters | ||||||
Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||
Deposited On: | 02 May 2016 23:28 | ||||||
Last Modified: | 02 Mar 2024 01:51 |
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